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Updated: Jun 23, 2025

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在阿尔茨海默病中,mTOR 抑制以 APOE 基因型依赖的方式增强突触和线粒体功能

Basavaraju G Sanganahalli1,2, Jelena M Mihailovic1,2, Hemendra J Vekaria3,4,5

  • 1Magnetic Resonance Research Center (MRRC), Yale University, New Haven, CT, USA.

Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism
|June 16, 2024
PubMed
概括

拉巴胺在携带APOE4基因的小鼠中改善了大脑功能,可能减轻阿尔茨海默病的风险. 根据APOE基因型,对Rapamycin的反应有所不同,这表明需要个性化医疗方法.

关键词:
在APOE4OE4中使用.阿尔茨海默氏症是阿尔茨海默氏症的一种疾病.拉帕米辛是一种线粒体功能 线粒体功能突触活动突触活动.

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