儿童代谢 (功能障碍) 相关的脂肪肝疾病:当前的见解和未来的前景
Sunitha Vimalesvaran1, Pietro Vajro2, Anil Dhawan3
1Paediatric Liver, Gastroenterology and Nutrition Centres, King's College Hospital NHS Trust, London, UK.
Hepatology international
|June 16, 2024
概括
代谢 (功能障碍) 相关的脂肪肝疾病 (MAFLD) 是儿童和成人脂肪肝的新术语,取代了非酒精性脂肪肝疾病 (NAFLD). 这种变化能让人们更好地了解病情.
科学领域:
- 肝病学 肝病学是一种肝病学.
- 儿科胃肠病学 儿科胃肠病学
- 代谢障碍 代谢障碍 代谢障碍
背景情况:
- 非酒精性脂肪性肝病 (NAFLD) 这个术语因其在儿科患者群体中的适当性而受到批评.
- 与代谢 (功能障碍) 相关的脂肪肝疾病 (MAFLD) 被提出作为一个更准确和更全面的命名.
- 在全球范围内,MAFLD的患病率正在增加,反映了肥胖率,现在是儿童和成人慢性肝病的首要原因.
研究的目的:
- 审查从NAFLD到MAFLD的术语的转变.
- 讨论MAFLD在儿童群体中的影响.
- 为儿童MAFLD提供当前理解和新兴治疗方法的概述.
主要方法:
- 对最近的研究和拟议的命名规范变更的文献综述.
- 对导致MAFLD的病因因素的分析.
- 讨论诊断挑战和治疗策略.
主要成果:
- MAFLD分类为脂肪肝疾病病因学提供了更全面的理解.
- 承认MAFLD是一种独立的疾病有助于将其与其他代谢障碍区分开来.
- 准确的诊断仍然具有挑战性,尽管在非侵入性生物标志物方面取得了进展,但往往需要成像和组织学.
结论:
- 采用MAFLD术语代表了理解和分类脂肪肝疾病的重大进步.
- 儿童MAFLD需要仔细评估,以排除其他遗传代谢障碍.
- 改变生活方式至关重要,对新型治疗剂的研究正在进行中.
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