间歇性缺失患者报告结果数据的原因与缺失数据机制之间的关系
Lene Kongsgaard Nielsen1,2, Rebecca Mercieca-Bebber3, Sören Möller4,5
1Department of Haematology, Quality of Life Research Center, Odense University Hospital, Odense, Denmark. lene.kongsgaard.nielsen@rsyd.dk.
概括
对患者报告的结果问卷没有反应的原因很重要. 由于健康问题而导致的不响应表明缺失的数据不是随机的,而技术问题表明缺失的数据完全是随机的.
科学领域:
- 临床研究 临床研究
- 生物统计学 生物统计学
- 健康 结果 研究 研究 结果
背景情况:
- 对患者报告结果 (PRO) 问卷的不响应可以在临床研究中引入偏见.
- 了解没有响应的原因对于适当的数据处理至关重要.
- 没有响应的原因和缺失数据机制之间的关系尚未得到充分理解.
研究的目的:
- 调查PR问卷中间歇性不响应 (NR) 的原因与缺失数据机制之间的关联.
- 确定NR的特定原因是否与不随机缺失 (MNAR) 或完全随机缺失 (MCAR) 机制一致.
主要方法:
- 多发性骨髓瘤患者随着时间的推移完成了PRO问卷.
- 没有回复被定义为未能在七天内完成问卷,促使后续行动.
- 记录了NR的原因,并将救援响应得分与以前的准时得分进行了比较,使用线性回归推断缺失数据机制 (MNAR与MCAR).
主要成果:
- 96%的后续问卷被填写,其中11%是救援回复.
- 由于住院,精神或身体原因而导致的不响应与10/22领域的PRO得分较差有关.
- 由于技术问题或被忽视的原因而导致的不响应在大多数领域的PRO得分中没有显著差异.
结论:
- 与住院或健康原因相关的间歇性不响应表明,近一半的PRO域缺失了非随机 (MNAR) 机制.
- 由于技术困难或被遗忘的问卷而导致的不响应通常与缺失完全随机 (MCAR) 机制保持一致.
相关概念视频
Mechanistic Models: Compartment Models in Individual and Population Analysis
36
Mechanistic models are utilized in individual analysis using single-source data, but imperfections arise due to data collection errors, preventing perfect prediction of observed data. The mathematical equation involves known values (Xi), observed concentrations (Ci), measurement errors (εi), model parameters (ϕj), and the related function (ƒi) for i number of values. Different least-squares metrics quantify differences between predicted and observed values. The ordinary least...
36
Assumptions of Survival Analysis
121
Survival models analyze the time until one or more events occur, such as death in biological organisms or failure in mechanical systems. These models are widely used across fields like medicine, biology, engineering, and public health to study time-to-event phenomena. To ensure accurate results, survival analysis relies on key assumptions and careful study design.
121
Data Reporting and Recording
4.6K
Reporting and recording are crucial in data documentation. The timely, thorough, and accurate documentation of facts is essential when recording patient data. Failure to record findings during an assessment or interpretation of a problem will result in loss of information and make the patient document unreliable. The reader is left with general impressions if the information is not specific. A recording is documenting data of the individual's health information in a traceable, secure, and...
4.6K
Censoring Survival Data
78
Survival analysis is a statistical method used to analyze time-to-event data, often employed in fields such as medicine, engineering, and social sciences. One of the key challenges in survival analysis is dealing with incomplete data, a phenomenon known as "censoring." Censoring occurs when the event of interest (such as death, relapse, or system failure) has not occurred for some individuals by the end of the study period or is otherwise unobservable, and it might have many different...
78
Documentation of Nursing Diagnosis
1.2K
The nurse documents nursing diagnoses and enters them into the patient record. The identified patient's nursing diagnosis is either written out with a plan of care or entered into the electronic health record.
In some settings, data-driven computerized decision support systems are in place, allowing for more accurate nursing diagnoses. The database within one of these systems includes diagnostic labels defining characteristics, activities, and indicators for nursing. A nurse enters...
In some settings, data-driven computerized decision support systems are in place, allowing for more accurate nursing diagnoses. The database within one of these systems includes diagnostic labels defining characteristics, activities, and indicators for nursing. A nurse enters...
1.2K
Methods of Documentation II: POMR
936
The Problem-Oriented Medical Record (POMR) revolutionized medical record-keeping by introducing a systematic approach focusing on the patient's problems rather than merely listing symptoms. Dr. Lawrence Weed's introduction of this method in the 1960s marked a significant advancement in medical documentation. The POMR framework consists of four key components: the database, problem list, plan of care, and progress notes.
936


