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增长差异化因子15 (GDF15) 水平与急性住院老年人营养不良有关

Rikke Lundsgaard Nielsen¹, Olivia Bornæs¹, Esben Iversen²

¹Department of Clinical Research, Copenhagen University Hospital Amager and Hvidovre, Kettegaard Allé 30, 2650 Hvidovre, Denmark; Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Blegdamsvej 3B, 2200 Copenhagen N, Denmark.

Clinical nutrition (Edinburgh, Scotland)

|June 16, 2024

概括

在老年人中,高水平的生长分化因子15 (GDF15) 与营养不良,食欲不佳和身体功能下降有关. 这一发现突出了GDF15作为老年人与衰老相关的健康下降的潜在生物标志物.

科学领域:

老年学是一门学科.
生物标志物生物标志物
代谢过程中的代谢.

背景情况:

衰老与营养不良的风险增加和增长差异化因子15 (GDF15) 水平的升高有关.
虽然GDF15已被公认为一种代谢调节剂,但其在老年人营养不良和衰老症状中的作用尚未得到充分研究.
研究GDF15与老年人营养状况,食欲和身体功能之间的关联至关重要.

研究的目的:

研究急性住院老年人血GDF15水平与营养状况之间的关系.
确定GDF15水平与老年人的食欲和身体功能标志物之间的关联.
探索GDF15作为营养不良和衰老中的功能衰退的潜在生物标志物.

主要方法:

血GDF15测量了302名进入急诊室 (ED) 的老年人 (≥65岁).
评估了营养状况 (MNA®-SF),食欲 (SNAQ) 和身体功能 (握手强度,30s椅子站立,步行速度).
用对年龄,性别和CRP进行调整的后勤回归分析来确定关联.

主要成果:

血GDF15的每一次翻倍都与营养不良的风险增加显著相关 (OR 1.59).
较高的GDF15水平与食欲不佳 (OR1.63),手握强度低 (OR1.46),椅子站 (OR1.74) 和步行速度测试 (OR1.99) 的表现下降相关.
这些关联在调整年龄,性别和C反应蛋白后仍然显著.

结论:

在接受ED治疗的老年人中,高GDF15水平与营养不良独立相关.
较高的GDF15与老年人群的食欲下降和身体功能较差有关.
GDF15可以作为一种有价值的生物标志物,用于识别老年人的营养不良和功能衰退.

关键词:

胃口胃口胃口慢性炎症是一种慢性炎症.紧急护理紧急护理营养不良营养不良营养不良年龄较大的成年人.物理功能物理功能

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