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Updated: Jun 23, 2025

The Isolation of Flowing Mesenteric Lymph in Mice to Quantify In Vivo Kinetics of Dietary Lipid Absorption and Chylomicron Secretion
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APOA5 缺乏导致过高甘油三血症,因为它减少了毛细血管中脂蛋白脂酶的量

Ye Yang1, Robert J Konrad2, Michael Ploug3

  • 1Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA, USA; Department of Human Genetics, David Geffen School of Medicine, University of California, Los Angeles, CA, USA.

Journal of lipid research
|June 16, 2024
PubMed
概括

脂蛋白AV (APOA5) 缺乏导致高甘油三通过增加ANGPTL3/8活动,从而降低脂蛋白脂酶 (LPL) 水平. 恢复APOA5功能将LPL和甘油三水平正常化.

关键词:
ANGPTL3/8/8/8/8/8/8/8/8/8 这是一个很好的例子.在APOA5A5中使用.过高甘油三糖血症的发生.脂蛋白脂酶是一种脂蛋白脂酶.这是一种单克隆抗体.

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