可修改的风险因素与脆弱性进展之间的关联在患有脆弱性前的个体中
Lanzhi Duan1, Mengmeng Xiao2, Sijia Liu1
1School of Basic Medicine, JingGangshan University, Ji'an, Jiangxi Province, China; Online Collaborative Research Center for Evidence-Based Medicine Ministry of Education, JingGangshan Univesity Branch, China; Affiliated Hospital of Jinggangshan University, Center for Clinical Medicine Research of Jinggangshan University, Ji'an 343000, China.
Experimental gerontology
|June 16, 2024
概括
保持健康的生活方式因素,如正常的体重指数和避免腹部肥胖,可以帮助那些在脆弱前恢复到健康状态的人. 相反,不健康的习惯增加了老年人虚弱进展的风险.
科学领域:
- 老年学与公共卫生
- 老龄化和脆弱性研究研究
- 预防医学 预防医学
背景情况:
- 全球老龄化是一个显著的人口趋势,中国正在经历快速增长的老年人口.
- 虚弱,一种与衰老相关的疾病,对老年人构成重大健康风险.
- 脆弱前期,以脆弱指数 (FI) >0.10至<0.25来定义,是干预的关键阶段.
研究的目的:
- 调查可修改的风险因素与中国人最初处于脆弱前状态的脆弱性进展之间的关联.
- 确定特定的生活方式因素,影响从脆弱前转向脆弱或恢复到健康状态的过渡.
主要方法:
- 分析了5,411名中年和老年中国参与者的队列,这些参与者最初以32项脆弱指数被描述为脆弱前.
- 评估了可修改的因素,包括体重指数 (BMI),腹部肥胖,吸烟,饮酒和睡眠状态.
- 使用后勤回归模型来检查这些因素,综合分数和脆弱状态在平均6年随访期间的变化之间的关系.
主要成果:
- 较高的BMI (≥25 kg/m2) 和腹部肥胖与恢复到健康状态的可能性较低有关 (分别为OR=0.59和OR=0.74).
- 脆弱性进展的增加与更高的可修改因子得分显著相关,特别是3或4的得分 (OR=1.12至1.52).
- 分层分析显示,农村的45-60岁的未婚男性,不到高中教育,更容易患上虚弱的进展,特别是腹部肥胖.
结论:
- 优化可修改的生活方式因素,在个体前脆弱性显著提高恢复到健康状态的机会.
- 相反,不利的可修改因素增加了进展到更严重的脆弱状态的风险.
- 针对可修改的风险因素的有针对性的干预措施对于管理老龄化人口的脆弱性进展至关重要.
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