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Updated: Jun 23, 2025

A Primary Neuron Culture System for the Study of Herpes Simplex Virus Latency and Reactivation
12:22

A Primary Neuron Culture System for the Study of Herpes Simplex Virus Latency and Reactivation

Published on: April 2, 2012

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α7尼古丁受体的激活减轻了微质细胞中的单纯疹病毒1型感染

Shih-Heng Chen1, Joanne C Damborsky2, Belinda C Wilson1

  • 1Viral Vector Core Facility, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC, USA; Neurobiology Laboratory, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC, USA.

Antiviral research
|June 16, 2024
PubMed
概括

阿尔法-7尼古丁性乙胆受体 (α7 nAChRs) 激动剂抑制了简单疹病毒1型 (HSV-1) 在微中的复制. 这种新的机制调节了先天的免疫反应,为抗神经炎症提供了潜在的治疗策略.

关键词:
胆 胆 是一种基因表达 基因表达 基因表达简单疹病毒1型 (HSV-1)炎症 炎症是一种炎症.微质细胞中的微质细胞PNU-28298787 是一个国家.α7 尼古丁性乙胆受体 (α7 nAChRs) 是一种

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Cholinergic Receptors: Nicotinic01:15

Cholinergic Receptors: Nicotinic

Nicotinic receptors are ligand-gated ion channels that are activated by acetylcholine and nicotine. Upon activation, they cause a rapid increase in the permeability of cells to K+, Na+, and Ca2+, followed by depolarization and excitation. They are in the autonomic ganglia, skeletal neuromuscular junction, CNS, and adrenal medulla.
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The pharmacological actions of acetylcholine are elicited via its binding to two families of cholinergic receptors or cholinoceptors, namely, muscarinic and nicotinic receptors. Muscarinic receptors are G protein-coupled receptors and have five subtypes, M1–M5. All mAChR subtypes are activated by acetylcholine and blocked by the antagonist, atropine. 
The subtypes M1, M3, and M5 couple with the Gq subunit and activate the phospholipase C (PLC) activity, mobilizing intracellular Ca2+....
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