皮肤交感神经活动在症状和无症状的 Paroxysmal 心房动
Jessica Mao1, Xiao Liu1, Anxhela Kote1
1Department of Cardiology, Smidt Heart Institute, Cedars-Sinai Medical Center, Los Angeles, California.
Heart rhythm
|June 16, 2024
概括
偏激性心房动 (AF) 的症状可以通过皮肤交感神经活动 (SKNA) 而不是心律更好地预测. 在症状发作期间观察到较高的SKNA水平,无论心律是AF还是正常的鼻节律 (NSR).
科学领域:
- 心脏病学 心脏病学
- 自主神经系统研究 自主神经系统研究
- 医疗监测 医疗监测
背景情况:
- 患有阳性心房动 (AF) 患者所经历的症状的起源尚未完全理解.
- 研究自主神经系统在AF症状产生中的作用对于了解患者体验至关重要.
研究的目的:
- 确定皮肤交感神经活动 (SKNA) 的强度与帕洛克性AF患者的症状发生之间的关系.
- 为了比较症状和无症状发作期间的SKNA水平,无论是AF还是正常鼻节律 (NSR).
主要方法:
- 预期招募患有症状性帕洛克性心肌梗塞的患者进行同时的门诊心电图和SKNA监测.
- 在症状发作期间心律的分类为AF或NSR.
- 利用混合效应模型来比较症状和无症状发作之间的最大和平均SKNA (aSKNA) 和心率 (HR),并考虑患者内部的相关性.
主要成果:
- 与无症状的AF发作相比,有症状的AF发作表现出显著更高的最大aSKNA和HR.
- 症状性NSR发作也显示最大aSKNA和HR显著高于无症状NSR发作.
- 大多数症状发作 (73%) 发生在NSR期间,而27%发生在AF期间.
结论:
- 偏激性AF患者的症状发作通常与正常鼻节律 (NSR) 相关,而不是AF.
- 在症状发作期间,无论底层心律 (AF或NSR) 是什么,都会持续观察到aSKNA水平升高.
- 皮肤交感神经活动 (SKNA) 显示,与心律单独相比,在性肌痛肌痛患者中,与症状体验的相关性更强.
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