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母亲吸烟暴露对COPD在后代小鼠的进展的影响

Jiawei Sun¹, Huan Chen², Xu Xu¹

¹Department of Respiratory Medicine, The First Hospital of Hebei Medical University, Shijiazhuang 050031, China.

Reproductive toxicology (Elmsford, N.Y.)

|June 16, 2024

概括

孕妇在怀孕期间和怀孕前吸烟会损害后代的肺功能,并导致细胞损伤,增加患慢性阻塞性肺病 (COPD) 的易感性. 这项研究强调了产前烟雾暴露对呼吸系统健康的持久影响.

科学领域:

呼吸系统医学呼吸系统医学
毒理学毒理学毒理学
发展生物学发展生物学

背景情况:

母亲吸烟是对后代呼吸系统不良结果的重要危险因素.
慢性阻塞性肺病 (COPD) 是一种具有复杂病因的渐进性肺病.
了解COPD的发育起源对于预防策略至关重要.

研究的目的:

调查母亲暴露于香烟烟雾 (CSE) 对后代呼吸健康的长期影响.
为了确定暴露时间 (怀孕前与怀孕前) 是否会影响COPD进展标志物.
阐明基底的细胞和分子机制CSE诱导后代的肺损伤.

主要方法:

一个使用C57BL/6J小鼠在不同生殖阶段 (怀孕前,怀孕或两者) 暴露于CSE的小鼠模型.
使用各种生理测试 (例如,Penh,PAU,TVb,EF50,Tr) 评估后代的肺功能.
组织病理学检查,电子显微镜,流细胞计和蛋白质分析,以评估肺组织损伤,亡和线粒体功能.

主要成果:

暴露于母体CSE的后代在所有暴露组中都表现出肺功能显著受损.
孕产妇的CSE导致肺病变,亡增加,以及后代肺细胞中的线粒体功能障碍.
暴露时间和持续时间影响了肺损伤的严重程度,怀孕前和怀孕期间的联合暴露显示了最明显的效应.
在后代的肺组织中观察到与亡相关的蛋白质表达的改变,包括降低Bcl-2.

结论:

无论暴露时间如何,母亲吸烟都会严重损害后代的肺部发育和功能.
CSE诱导肺病变,线粒体功能障碍,并改变后代的亡途径,有助于COPD易感性.
这些发现强调了预防母亲吸烟的必要性,以减轻未来几代人患呼吸道疾病的风险.

关键词:

慢性慢性肺炎是一种慢性慢性肺炎,COPD是一种慢性肺炎.细胞亡是细胞的亡.暴露于香烟烟雾中的情况.线粒体功能障碍线粒体功能障碍在VDAC-1中使用VDAC-1.

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