不同PIP动机的PCNA分子识别:Tyr211酸化的作用

Antonio Ruiz-Albor1, Belén Chaves-Arquero1, Inés Martín-Barros2

  • 1Centro de Investigaciones Biológicas Margarita Salas (CIB), CSIC, Madrid 28040, Spain.

概括

在Y211的增殖细胞核抗原 (PCNA) 酸化对关键调节蛋白p21和p15的结合影响最小. 这种修改也影响与DNA聚合酶 δ (p125) 和USP29的结合,但亲和力非常低.

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