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Updated: Jun 23, 2025

Determination of the Relative Potency of an Anti-TNF Monoclonal Antibody mAb by Neutralizing TNF Using an In Vitro Bioanalytical Method

Determination of the Relative Potency of an Anti-TNF Monoclonal Antibody mAb by Neutralizing TNF Using an In Vitro Bioanalytical Method

Published on: September 16, 2017

反向遗传学应用于瘤坏死因子的免疫生物学,一个多功能细胞因子

Sergey A Nedospasov^1,2, Andrei A Kruglov³, Alexei V Tumanov⁴

¹Division of Immunobiology and Biomedicine, Sirius University of Science and Technology, Federal Territory Sirius, 354340, Russia. sergei.nedospasov@gmail.com.

Biochemistry. Biokhimiia

|June 16, 2024

概括

瘤亡因子 (TNF) 是一种细胞因子,在免疫系统中具有复杂的作用. 早期的研究集中在它的抗瘤作用上,但新的研究揭示了它在健康和疾病中的真正功能.

科学领域:

免疫学免疫学免疫学
分子生物学分子生物学
遗传学是一个遗传学.

背景情况:

细胞因子,如瘤亡因子 (TNF),是免疫系统中关键的信号分子.
在实验模型中,TNF最初因其强大的抗瘤特性而被认可.
它在体内的主要生理作用与瘤抑制不同.

研究的目的:

审查TNF在生理和病理条件下确定的功能.
讨论基因工程小鼠模型在理解TNF中的实用性.
探索TNF依赖性疾病的治疗策略.

主要方法:

利用早期的基因组编辑技术,创建"人造"小鼠模型.
分析这些模型以阐明TNF的真正生物学功能.
审查有关TNF在健康和疾病中的作用的现有文献.

主要成果:

转基因小鼠模型在揭示TNF的实际生理作用方面发挥了重要作用.
TNF的功能超越抗瘤活性,影响健康和疾病的各个方面.
这些模型提供了对TNF依赖性病理背后的机制的洞察.

结论:

早期的基因组编辑技术,特别是在小鼠模型中,对于理解TNF真正的生物学意义至关重要.
在免疫系统中,TNF扮演着多方面的角色,与其最初观察到的抗瘤作用分开.
使用这些模型进行进一步的研究可以指导开发用于涉及TNF的疾病的改进疗法.

关键词:

这就是TNF TNF.有条件的小鼠模型.基因淘汰赛基因淘汰赛过度表达的基因表达过度.记者小鼠记者小鼠瘤死亡因子是瘤死亡因子.

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