为良性疾病进行全甲状腺切除术后永久性甲状腺缺血症患者的长期结局:基于人口的研究
Yan Luk1, Matrix Man Him Fung1, David Tak Wai Lui2
1Department of Surgery, The University of Hong Kong, Queen Mary Hospital, Hong Kong.
Surgery
|June 16, 2024
概括
甲状腺手术后的永久性甲状腺功能低下症显著增加了损伤的风险. 患有这种疾病的患者的功能下降速度更快,持续估计的膜过率下降率更高.
科学领域:
- 内分泌学 在内分泌学.
- 腎臟病學 (nephrology) 是一種醫學.
- 手术并发症 手术并发症
背景情况:
- 永久性甲状腺缺血是完全甲状腺切除术后的一个已知的并发症.
- 这种情况可能会对患者的长期健康产生影响.
研究的目的:
- 为了研究永久性甲状腺缺血症在全甲状腺切除术后对功能的长期影响.
- 为了确定术后缺甲状腺症和结局之间的关联.
主要方法:
- 对3245名接受全甲状腺切除术 (1999-2014) 的患者进行了回顾性分析.
- 定义为永久性偏偏甲状腺症,需要口服/维生素D进行手术后6个月以上的治疗.
- 通过估计的淋巴细胞过率 (eGFR) 评估功能,并监测持续的eGFR下降 (≥50%) 和末期病.
主要成果:
- 12.9%的患者患有永久性副副甲状腺功能障碍.
- 患有永久性甲状腺功能低下症的患者表现出持续性EGFR下降率显著更高 (15.6%对6.9%,P<.001).
- 永久性缺甲状腺症是降低功能的一个独立风险因素 (aHR2.77,P <.001) 并与更快的EGFR下降相关 (-1.60 vs -0.70 mL/min/1.73 m2/year).
结论:
- 手术后永久性甲状腺功能低下症与功能障碍的风险增加有关.
- 在甲状腺切除术期间改善副甲状腺的识别和保存对于降低患者的发病率至关重要.
相关概念视频
00:59The Parathyroid Glands
2.0K
The two pairs of parathyroid glands embedded within the posterior surface of the thyroid gland are restricted by a dense capsule around them. These glands comprise two distinct cell populations—parathyroid oxyphil and parathyroid principal cells- pivotal in calcium homeostasis.
Oxyphil cells, whose functions remain elusive, emerge during late puberty, adding a layer of complexity to the parathyroid gland's intricacies. In contrast, principal parathyroid cells undertake a vital role by...
Oxyphil cells, whose functions remain elusive, emerge during late puberty, adding a layer of complexity to the parathyroid gland's intricacies. In contrast, principal parathyroid cells undertake a vital role by...
2.0K
01:17Hormones and Bone Tissue
2.7K
The endocrine system produces and secretes hormones, which interact with the skeletal system. These hormones control bone growth, maintain bone once it is formed, and remodel it.
Hormones That Influence Osteoblasts and/or Maintain the Matrix
Several hormones are necessary for controlling bone growth and maintaining the bone matrix. The pituitary gland secretes growth hormone (GH), which, as its name implies, controls bone growth. This happens in several ways: first, it triggers chondrocyte...
Hormones That Influence Osteoblasts and/or Maintain the Matrix
Several hormones are necessary for controlling bone growth and maintaining the bone matrix. The pituitary gland secretes growth hormone (GH), which, as its name implies, controls bone growth. This happens in several ways: first, it triggers chondrocyte...
2.7K
01:21Skeleton and Calcium Homeostasis
4.5K
Calcium is not only the most abundant mineral in bone but also the most abundant mineral in the human body. Calcium ions are needed for bone mineralization, tooth health, heart rate regulation and strength of contraction, blood coagulation, the contraction of smooth and skeletal muscle cells, and the regulation of nerve impulse conduction. The average calcium level in the blood is about 10 mg/dL. When the body cannot maintain this level, a person will experience hypo or hypercalcemia.
4.5K