使用序列行为和血清流行数据分析注射毒品的人群中HCV发病率趋势:一项建模研究
Conor Egan1, Ross J Harris2, Holly D Mitchell2
1MRC Biostatistics Unit, University of Cambridge, United Kingdom.
The International journal on drug policy
|June 16, 2024
概括
型肝炎病毒 (HCV) 发病率很难衡量,但新的方法显示,尽管治疗规模扩大,但新药注射者中的发病率正在上升. 监测感染发病率是实现HCV消除目标的关键.
科学领域:
- 流行病学 流行病学
- 公共卫生 公共卫生
- 传染性疾病 传染性疾病
背景情况:
- 世界卫生组织 (WHO) 启动了使用直接作用抗病毒药物消除C型肝炎病毒 (HCV) 的战略.
- 减少HCV发病率是一个关键目标,但直接测量是具有挑战性的.
研究的目的:
- 估计英格兰,威尔士和北爱尔兰注射毒品的人群中HCV发病率.
- 为了比较从血清流行率数据估计发病率的统计方法.
主要方法:
- 使用了连续的横截面生物行为血清调查 (非链接匿名监测调查).
- 采用灵活的参数和半参数模型 (分数多项式,splines) 来估计暴露时间和调查年份的发病率.
主要成果:
- 发病率在近期入门者中达到0.20个感染人/年,在长期注射者中降至0.05.
- 在2011年至2020年期间,在最近的初心者中观察到发病率的上升 (每人/年0.17至0.26).
- 在长时间内注射药物的人群中,发病率保持稳定.
结论:
- 分裂模型可能比分数多项式更灵活地检测短期发病率变化.
- 尽管治疗规模扩大,但没有观察到HCV首次感染率的下降.
- 血清发病率和风险行为数据对于估计和监测HCV发病率以实现消除目标至关重要.
相关概念视频
Retrovirus Life Cycles
45.8K
Retroviruses have a single-stranded RNA genome that undergoes a special form of replication. Once the retrovirus has entered the host cell, an enzyme called reverse transcriptase synthesizes double-stranded DNA from the retroviral RNA genome. This DNA copy of the genome is then integrated into the host’s genome inside the nucleus via an enzyme called integrase. Consequently, the retroviral genome is transcribed into RNA whenever the host’s genome is transcribed, allowing the...
45.8K
Healthcare Associated Infections II: Preventive Measures
2.6K
Essential infection prevention measures are based on the knowledge of the infection chain, the modes of transmission in healthcare settings, and the use of the best practices in all healthcare settings. Compulsory public reporting of healthcare-associated infection rates is needed to allow individuals and the community to make informed choices regarding selecting a healthcare facility.
The best practices for preventing healthcare-associated infections include hand hygiene, patient risk...
The best practices for preventing healthcare-associated infections include hand hygiene, patient risk...
2.6K
Pulmonary Tuberculosis I
231
Tuberculosis, often called TB, is a contagious illness primarily caused by Mycobacterium tuberculosis. It mainly affects the lung parenchyma but can also impact other body parts.
Causative Organism
The primary infectious agent causing tuberculosis is Mycobacterium tuberculosis, a slow-growing, acid-fast, aerobic rod that exhibits sensitivity to heat and ultraviolet light. Instances of Mycobacterium bovis and Mycobacterium avium contributing to the development of TB infection are rare.
Mode of...
Causative Organism
The primary infectious agent causing tuberculosis is Mycobacterium tuberculosis, a slow-growing, acid-fast, aerobic rod that exhibits sensitivity to heat and ultraviolet light. Instances of Mycobacterium bovis and Mycobacterium avium contributing to the development of TB infection are rare.
Mode of...
231
Sexually Transmitted Infections
299
Sexually transmitted infections (STIs) are diseases transmitted primarily through unsafe sexual interactions. Bacteria, viruses, or parasites cause them and can result in severe health complications if untreated.ChlamydiaThe bacterium Chlamydia trachomatis is responsible for the disease Chlamydia, the most common STI in the United States. This peculiar pathogen requires human cells to reproduce, residing intracellularly. The initial infection often goes unnoticed because it typically does not...
299


