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Updated: Jun 23, 2025

Assessment of Mitochondrial Health in Cancer-Associated Fibroblasts Isolated from 3D Multicellular Lung Tumor Spheroids
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PDLIM2下调的瘤促进作用涉及线粒体ROS,代谢体积和HIF-1α激活

Jing-Xing Yang1, Yu-Chen Chuang1, Jen-Chih Tseng1

  • 1Immunology Research Center, National Health Research Institutes, Zhunan, Miaoli, 35053, Taiwan.

Journal of experimental & clinical cancer research : CR
|June 16, 2024
PubMed
概括

降低PDZ和LIM域2 (PDLIM2) 调控通过损害线粒体功能和激活缺氧诱导因子-1α (HIF-1α) 来促进肺癌. HIF-1α抑制剂在治疗低PDLIM2表达的肺癌方面表现有前途.

关键词:
这就是HIF-1α.这是一种HIF-1α抑制剂.线粒体中的线粒体.在PDLIM2中,PDLIM2是苏酸盐是一种酸盐.Succinate 脱水酶 的作用.

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