在非洲不同环境中药物不良事件的变化:系统性审查
Linda Nyame1, Yuhua Hu2, Hui Xue2
1School of Public Health, Southeast University, Nanjing, China. Lindanimeson@163.com.
European journal of medical research
|June 16, 2024
概括
药物不良事件 (ADEs) 是非洲医疗保健的一个重大挑战. 本次审查强调了ADE的高患病率,特别是在特定的患者群体中,这表明需要有针对性的干预措施和进一步的社区研究.
科学领域:
- 非洲医疗保健系统中的药物监测.
- 药物不良事件的流行病学 (ADEs) 在不同的医疗保健环境.
- 非洲药物安全对公共卫生的影响.
背景情况:
- 药物不良事件 (ADEs) 对非洲医疗保健系统构成重大挑战,增加成本并对患者健康结果产生负面影响.
- 了解ADEs的患病率和模式对于制定有效的公共卫生策略和改善药物安全至关重要.
- 本系统性审查综合了各种非洲医疗保健机构对ADE患病率的现有证据.
研究的目的:
- 系统地审查和综合现有关于非洲各个医疗保健机构中药物不良事件 (ADEs) 患病率的证据.
- 识别ADE发生的趋势和模式,为公共卫生干预和药物安全监测提供信息.
主要方法:
- 在主要数据库 (PubMed,EBSCO,Science Direct,Web of Science) 进行了全面的文献搜索,查找2000年1月1日至2023年10月1日期间发表的研究.
- 研究的分类是基于它们是否研究了一般的ADEs或与特定疾病 (例如HIV) 或药物 (例如抗生素) 相关的特定ADEs.
- 使用中位数和四分位数间范围 (IQR) 分析了患病率,以描述来自15个非洲国家78项观察研究的发现.
主要成果:
- 该审查包括来自15个非洲国家的78项研究,检查了在入院,住院期间和门诊/社区环境中的ADEs.
- 住院期间ADE中位数的患病率为7.8% (一般患者) 和74.2% (特定患者).
- 门诊和社区ADE患病率分别为22.9%和32.6%,其中很大一部分可预防的ADE (43.5%一般,12.4%特定患者).
结论:
- 药物不良事件在整个非洲的医院和社区环境中普遍存在,在特定患者群体中观察到的特别高的发病率.
- 需要改善药物安全措施,特别是对于儿童,艾滋病毒和结核病患者等风险群体.
- 由于该领域的研究有限,建议进一步关注社区环境的研究.
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