糖尿病外围神经病变与微量营养素的关联
Sandhya Gautam1, Chhaya Mittal2, Alok Ranjan3
1Professor, Department of Medicine, Lala Lajpat Rai Memorial Medical College, Meerut, Uttar Pradesh, India, Corresponding Author.
The Journal of the Association of Physicians of India
|June 17, 2024
概括
糖尿病外围神经病变与较低的和维生素B12水平显著相关. 在这项研究中,铜和水平与DPN没有显著的关联.
科学领域:
- 内分泌学 在内分泌学.
- 神经学 神经学
- 营养科学 营养科学
背景情况:
- 糖尿病 (DM) 具有高血糖的特征,通常涉及增加的氧化应激.
- 糖尿病患者由于线粒体功能障碍和血管炎症而表现出较高的微量营养素需求.
- 微量营养素失衡可能会导致糖尿病并发症的发展.
研究的目的:
- 研究糖尿病外围神经病变 (DPN) 与关键微量营养素血清水平之间的关联.
- 特别是检查铜 (Cu), (Zn), (Mg) 和维生素B12 (Vit B12) 与DPN相关.
主要方法:
- 一项涉及130名2型糖尿病患者的横截面研究.
- 使用密歇根州神经病变查仪器诊断出糖尿病外围神经病变.
- 微量营养素水平被测量并与DPN的存在相关联.
主要成果:
- 观察到DPN与较低的含量之间存在显著的关联 (p=0.02).
- 维生素B12缺乏也与DPN有显著的联系 (p=0.008).
- DPN与铜 (p=0.57) 或 (p=0.24) 含量之间没有发现显著的关联.
结论:
- 和维生素B12水平与糖尿病外围神经病变显著相关.
- 这些发现表明和维生素B12补充剂在管理DPN方面可能发挥作用.
- 需要进一步的研究来证实这些关联并探索治疗意义.
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