酸通过改善肠道屏障功能来抑制引起的结肠损伤
Shumin Wang1, Yan Hong1, Yuxiu Li1
1Department of Histology and Embryology, School of Basic Medicine, Guizhou Medical University, Guiyang, Guizhou, People's Republic of China.
Environmental toxicology
|June 17, 2024
概括
酸 (FA) 通过减少氧化应激和炎症来保护免受引起的肠损伤. FA 维护了肠道屏障的完整性,可能是暴露引起的结肠损伤的潜在治疗方法.
科学领域:
- 毒理学 毒理学 毒理学
- 胃肠病学 胃肠病学
- 生物化学 生化学
背景情况:
- 暴露会导致肠道屏障功能障碍,氧化应激和炎症.
- 酸 (FA) 具有抗氧化和抗炎性质,可以减轻引起的其他器官损伤.
- 对于FA保护肠道免受毒性的潜力还没有被探索.
研究的目的:
- 研究ferulic acid (FA) 对引起的肠损伤的保护作用.
- 阐明涉及紧结蛋白,氧化应激和关键信号通路的潜在机制.
主要方法:
- 暴露于甲的小鼠接受了FA治疗,评估了结肠组织病理和紧结 (TJ) 蛋白质水平.
- 暴露于甲的Caco-2细胞被FA处理以评估氧化应激和TJ蛋白表达.
- 在结肠和Caco-2细胞中对NF-κB和Nrf2/HO-1通路进行了分子分析.
主要成果:
- 治疗FA改善了结肠粘膜的完整性,并逆转了引起的TJ蛋白的下调 (Claudin-1,Occludin,ZO-1).
- FA抑制了氧化应激和减弱了对Caco-2细胞TJ蛋白表达的抑制作用.
- 在暴露于的结肠和肠细胞中,FA抑制了NF-κB的激活,并恢复了Nrf2/HO-1通路的激活.
结论:
- 酸通过保持肠道上皮质紧密结合的完整性来减轻引起的肠损伤.
- 通过抑制氧化应激和调节NF-κB和Nrf2/HO-1通路,FA具有保护作用.
- 这些发现支持FA在引起的结肠损伤中的潜在治疗应用.
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