牙性大鼻炎微生物学与慢性鼻炎相比:一个元分析
Chang Lu1, Yue Zhao1, Yicheng Qin1
1Department of Stomatology, Beijing TongRen Hospital, Capital Medical University, Beijing, China.
American journal of rhinology & allergy
|June 17, 2024
概括
牙性大鼻炎 (OMS) 显示,与慢性鼻炎 (CRS) 相比,Fusobacterium的患病率更高. 金黄色葡萄球菌在CRS中更常见,有助于对这些鼻炎亚型的差异诊断和治疗策略.
科学领域:
- 耳鼻喉科 耳鼻喉科 耳鼻喉科
- 微生物学 微生物学
- 医学诊断 医学诊断 医学诊断
背景情况:
- 鼻炎亚型由于不同的病原体,具有不同的临床特征和预后.
- 牙性大鼻炎 (OMS) 通常是单边的,不同于双边慢性鼻炎 (CRS).
- 以前的OMS和CRS之间的微生物学比较是有限的,并且在方法上有偏见.
研究的目的:
- 进行全面的元分析,比较OMS和CRS的微生物学.
- 根据它们的微生物概况提供证据来区分OMS和CRS.
- 识别可能解释不同病理的关键细菌差异,并为诊断/治疗策略提供信息.
主要方法:
- 在PubMed和CNKI数据库中进行系统的文献搜索,截至2023年7月.
- 使用随机效应模型进行元分析,以估计细菌物种/属的聚合流行率.
- 包括包括OMS,CRS和正常鼻样本的17项研究.
主要成果:
- 分析包括191个OMS,610个CRS和92个正常鼻样本.
- 与CRS相比,fusobacterium在OMS中患病率显著更高.
- 黄金葡萄球菌被发现在CRS中比在WHO中更为普遍.
结论:
- 菌是一种关键的差异化因素,在OMS中比CRS更为普遍.
- 黄金葡萄球菌的患病率在CRS中更高,这表明不同的微生物病因.
- 微生物形状的差异支持OMS和CRS的新型诊断和治疗方法.
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