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对被诊断为中部早发性青春期的患者进行了回顾性评估,这些患者已经达到最终的身高

Kadri Yaman¹, Edip Unal¹, Aslı Beştaş¹

¹Department of Pediatric Endocrinology, 2064056 Faculty of Medicine, Dicle University , Diyarbakır, Türkiye.

Journal of pediatric endocrinology & metabolism : JPEM

|June 17, 2024

概括

治疗中部早熟青春期 (CPP) 的淋巴激素释放激素类似物 (GnRHa) 有效地帮助大多数女孩达到或超过目标身高. 最初的身高和预测的成年人身高是实现更大的最终身高的关键因素.

科学领域:

儿科内分泌学儿科内分泌学
生殖医学生殖医学
增长和发展增长和发展

背景情况:

中部早期青春期 (CPP) 涉及青春期的早期发作,需要治疗以控制发育.
CPP管理的主要目标是阻止或减缓青春期的进展.
评估影响GnRHa治疗患者最终身高的因素对于优化结果至关重要.

研究的目的:

为了确定与最终成年人身高相关的因素,GnRHa.治疗的女性CPP患者.
评估GnRHa治疗对体重指数 (BMI) 和青春期时间的影响.
为了确定录取参数和最终高度结果之间的关系.

主要方法:

对67名患有CPP的女性患者的医疗记录进行了回顾性分析.
收集的数据包括年龄,骨年龄 (BA),高度标准偏差得分 (SDS),BMI-SDS,目标高度-SDS和荷尔蒙水平.
还记录了盆腔超声检查结果和初潮时的年龄.

主要成果:

大多数患者 (94%) 在GnRHa治疗后达到或超过了目标身高.
超过目标身高的患者有更好的初始身高-SDS和预测的成人身高 (PAH).
目标身高-SDS对增高产生了积极的影响,而骨年龄与时间年龄 (BA/CA) 比例对其产生了负面影响. 治疗后BMI-SDS保持稳定.

结论:

在CPP的女孩中,GnRHa治疗有效地实现了令人满意的最终身高,其中很大一部分超过了他们的目标身高.
最初的高度-SDS和PAH是最终更高的重要预测因素.
GnRHa疗法不会对BMI-SDS产生负面影响,支持其安全性.

关键词:

中央早期青春期早期青春期最终的高度最终的高度.淋巴激素释放激素类比治疗的治疗方法

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