黑人和白人患者之间的阻塞性睡眠呼吸暂停中正气道压力要求的差异
Yi Cai1,2, Manan H Parekh1, Julianna Rodin1
1Department of Otorhinolaryngology-Head and Neck Surgery, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
概括
患有阻塞性睡眠呼吸暂停 (OSA) 的黑人和白人患者表现出类似的正气道压力 (PAP) 需求,表明可比的气道缩性. 这表明,尽管利用差异,但对PAP替代品的反应类似.
科学领域:
- 睡眠医学 睡眠医学
- 呼吸系统医学 呼吸系统医学
- 健康差异 在健康上的差异
背景情况:
- 黑人和白人患者在阻塞性睡眠呼吸暂停 (OSA) 时使用正气道压力 (PAP) 替代品存在显著差异.
- 黑人患者中PPP替代品的低利用率突出显示了他们对这些疗法的结果的知识差距.
- 治疗性PAP水平是PAP替代治疗成功的既定预测因素.
研究的目的:
- 调查和比较黑人和白人患者诊断出阻塞性睡眠呼吸暂停 (OSA) 之间的正气道压力 (PAP) 要求.
- 评估种族群体之间的PAP需求差异是否与上呼吸道缩性相关,这是OSA的一个关键因素.
- 为潜在的治疗策略提供信息,并解决OSA管理中的利用差异.
主要方法:
- 在一个学术睡眠中心进行了一项横截面研究.
- 包括OSA处方自调 PAP (2018-2020) 和呼吸暂停-呼吸暂停指数 (AHI) ≥10的患者.
- 线性回归分析了PAP水平的平均值和90百分点,控制年龄,性别,BMI,AHI,氧和和面具类型.
主要成果:
- 该研究包括157名黑人和234名白人患者,主要是严重的OSA和肥胖.
- 与白人患者相比,黑人患者的平均PAP (0.68厘米H2O) 和第90百分点PAP (0.85厘米H2O) 水平略高.
- 尽管这些差异具有统计学意义,但PAP要求的差异在临床上被认为是微不足道的.
结论:
- 在黑人和白人OSA患者之间,PAP要求的临床上微不足道的差异表明上呼吸道的可比性.
- 调查结果表明,这两个种族群体可能会基于可折叠性对PAP替代品作出类似的反应.
- 需要进一步的研究,以了解黑人患者中PAP替代品使用率低的根本原因.
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