基于智能手机报告的每日饮酒量与健康志愿者的PEth度之间的关系
Trine Finanger1,2, Katrine Melby3,4, Olav Spigset2,4
1Clinic of Substance Use and Addiction Medicine, St. Olav University Hospital, 7030 Trondheim, Norway.
Alcohol and alcoholism (Oxford, Oxfordshire)
|June 17, 2024
概括
每天的酒精消费与脂乙醇 (PEth) 水平相对相关,无论报告方法如何. 每天减少2个酒精单位可以将PEth降低0.1μmol/l,这表明有害饮酒的0.1μmol/lPEth截止值.
科学领域:
- 酒精消费的生物标志物 饮酒的生物标志物
- 临床化学 临床化学
- 成 药物 药物 药物 药物
背景情况:
- 脂乙醇 (PEth) 是一种敏感的生物标志物,用于检测最近的酒精消费.
- 准确评估酒精摄入量对于临床管理和公共卫生至关重要.
研究的目的:
- 为了检查通过智能手机日记追踪的每日酒精消费量与未被诊断为酒精使用障碍 (AUD) 的个体的血液PEth水平之间的关联.
- 为了准确地比较未来的数字日记注册与追溯的时间线追溯.
- 评估性别和身体质量指数 (BMI) 对酒精-PET关系的影响.
主要方法:
- 41名女性和21名没有AUD的男性前性地使用数字日记记录了14天内每天的酒精摄入量.
- 追溯的酒精消费数据是使用时间线追溯方法在同一时期收集的.
- 在14天的登记期之前和之后测量了PEth 16:0/18:1水平.
主要成果:
- 在日常饮酒量和PEth度之间观察到强烈的相关性 (0.650.87).
- 相关性保持一致,无论数据是前性还是后性收集.
- 性别和BMI并没有显著影响酒精摄入量和PEth水平之间的关联.
- 每天减少2个酒精单位 (26克乙醇) 与0.1μmol/l的PEth减少有关.
结论:
- PEth度可靠地反映了每天的酒精消耗,对于前性和后性报告方法都有很好的相关性.
- 最佳的PEth切断值应与有害酒精消费的门保持一致,平衡敏感性和特异性.
- 建议PETh截止值大约为0.1μmol/l,以确定每天消耗超过23个酒精单位的个体,灵敏度为8090%.
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