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Updated: Jun 23, 2025

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作为一个可行的新型洗剂,NDT-C11用于单颗粒冷电磁波

Chimari Jiko1, Jiannan Li2, Youngsun Moon3

  • 1Institute for Integrated Radiation and Nuclear Science, Kyoto University, Kumatori, Osaka, 590-0494, Japan.

ChemPlusChem
|June 17, 2024
PubMed
概括

一种新型洗剂NDT-C11显示出对整体膜蛋白单颗粒冷电子显微镜 (cryo-EM) 的前景. 与LMNG等常用的选项相比,这种新型洗剂可能会改善结构确定性.

关键词:
冰冷化EMEM可以使用.这是一种洗剂.膜蛋白是一种膜蛋白质.单个粒子分析玻璃化 玻璃化 玻璃化

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Conventional electron microscopy (EM) involves dehydration, fixation, and staining of biological samples, which distorts the native state of biological molecules and results in several artifacts. Also, the high-energy electron beam damages the sample and makes it difficult to obtain high-resolution images. These issues can be addressed using cryo-EM, which uses frozen samples and gentler electron beams. The technique was developed by Jacques Dubochet, Joachim Frank, and Richard Henderson, for...
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