高阿波利波蛋白B/阿波利波蛋白A1与2型糖尿病患者的维生素D缺乏有关
Shuqi Wang1,2, Haina Gao3, Mengmeng Zhang1,2
1Department of Internal Medicine, Hebei Medical University, Shijiazhuang, People's Republic of China.
概括
维生素D缺乏与2型糖尿病患者的阿波利波蛋白B/阿波利波蛋白A1比率较高有关. 这一比率是维生素D缺乏的一个独立风险因素,特别是在女性中.
科学领域:
- 内分泌学 在内分泌学.
- 代谢综合征是代谢综合征的一种.
- 营养生物化学 营养生物化学
背景情况:
- 2型糖尿病 (T2DM) 是一个与各种代谢并发症相关的全球健康问题.
- 阿波利波蛋白B/阿波利波蛋白A1 (apo B/A1) 的比例是失脂症和心血管风险的标志物.
- 维生素D缺乏在T2DM患者中很普遍,可能会影响血糖控制和心血管健康.
研究的目的:
- 研究2型糖尿病 (T2DM) 患者的维生素D (VitD) 水平与阿波利波蛋白B/阿波利波蛋白A1 (apo B/A1) 比率之间的关联.
- 确定apo B/A1比率是否是T2DM患者维生素D缺乏症的独立风险因素.
主要方法:
- 一项追溯性研究,涉及784名T2DM患者,持续2年6个月.
- 患者被分为VitD缺乏和非缺乏的组,以及高和低的ApoB/A1比率组.
- 统计分析包括相关性,多重线性回归,二进制物流回归和ROC曲线分析.
主要成果:
- 与没有缺乏症的患者相比,具有VitD缺乏症的T2DM患者的ApoB/A1比率显著更高 (P<0.001).
- 维生素D水平与apo B/A1比率 (r=-0.238,P<0.001) 呈负相关性,即使经过对其他因素进行调整 (β=-0.123,P=0.001).
- 在T2DM中,ApoB/A1比被确定为VitD缺乏的独立风险因素,观察到显著的线性关系 (P一般趋势<0.0001). 这种关联在女性患者中更为强烈.
结论:
- 在T2DM患者中,ApoB/A1比与VitD水平显著负相关.
- 升高的阿波B/A1比率在这个人群中充当了维生素D缺乏的独立风险因素.
- 这些发现表明,在T2DM中,对治疗失脂血症和VitD缺乏症的潜在治疗点.
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