老年骑马中的血代谢物度和酶活性的变化
Yukari Asahi1, Toshiro Arai1, Yoshikazu Tanaka1
1School of Veterinary Medicine, Nippon Veterinary and Life Science University, Musashino, Japan.
Frontiers in veterinary science
|June 17, 2024
概括
老年马的炎症增加和脂质代谢发生变化,由血清粉样蛋白A (SAA) 的上升表明. 早期识别SAA等引起炎症的生物标志物可能有助于预防与年龄相关的疾病.
科学领域:
- 兽医医学 兽医医学 兽医医学
- 马类生理学 马类生理学
- 衰老研究研究 衰老研究
背景情况:
- 马的衰老与降低代谢率和改变能量代谢有关.
- 与年龄相关的疾病和持续的低度炎症 (炎症) 随着年龄的增长而增加.
- 对炎症的早期干预可以预防马的与年龄有关的疾病.
研究的目的:
- 在临床上健康的老年骑马中识别炎症形成的生物标志物.
- 研究与能量代谢相关的血代谢物,激素和酶活动的变化.
- 评估老化,炎症和马中的脂质代谢之间的关系.
主要方法:
- 测量了血中甘油三 (TG),总胆固醇 (T-Cho),血尿素 (BUN),胰岛素,甲 (MDA) 和血清粉胺A (SAA) 的度.
- 评估了血腺素,超氧化物脱酶 (SOD) 和白细胞AMP激活蛋白激酶 (AMPK) 的活性.
- 在不同年龄的马中监测血亚斯巴酸胺转移酶 (AST),氨酸胺转移酶 (ALT) 和谷氨过氧化酶 (GPx).
主要成果:
- 血TG,T-Cho,BUN,胰岛素,MDA和SAA随着年龄的增长而增加.
- 随着年龄的增长,阿迪波内克丁,SOD和AMPK活动下降.
- 17岁以上的马体表现出炎症前兆和脂质代谢障碍,SAA显示出作为生物标志物的潜力.
结论:
- 血清粉样蛋白A (SAA) 可能作为一种有用的生物标志物,用于老年马的炎症和失调的脂质代谢.
- 骑马的持续运动可能会减轻炎症,但老年马仍然表现出炎症和代谢变化的迹象.
- 识别引起炎症的生物标志物对于预防马的与年龄有关的疾病至关重要.
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