在人类胃肠道液体模拟剂中从微塑料中分解多环芳香碳化合物 - - 对暴露评估的影响
Emeka Ephraim Emecheta1,2, Patrizia Marie Pfohl3, Wendel Wohlleben3
1Department of Chemical and Product Safety, German Federal Institute for Risk Assessment, Max-Dohrn-Straße 8-10, 10589 Berlin, Germany.
ACS omega
|June 17, 2024
概括
人类可能暴露在携带多环芳 (PAHs) 的微塑料中. 我们的研究表明,人类肠道中微塑料的PAH释放量很小,这表明饮食风险很低.
科学领域:
- 环境科学 环境科学
- 毒理学 毒理学 毒理学
- 食品安全 食品安全
背景情况:
- 微塑料在食品中普遍存在,导致人类暴露.
- 空中微塑料可以携带诸如多环芳 (PAH) 等污染物.
- 了解微塑料在胃肠道 (GIT) 中释放的污染物至关重要.
研究的目的:
- 为了研究PAHs从微塑料在模拟的人类消化液中的脱离.
- 在不同的GIT条件下量化各种微塑料中释放的子[a]烯.
- 评估微塑料吸收的PAHs对人类饮食总体摄入量的潜在贡献.
主要方法:
- 利用基于生理学的体外模型模拟人类消化 (唾液,胃,小肠和大肠液).
- 研究了从低密度聚乙烯 (LDPE),热塑性聚氨 (TPU) 和聚胺 (PA) 中的子[a]烯脱落.
- 在所有四种模拟的消化液中测量累积相对消化率 (CRD).
主要成果:
- 在模拟的唾液中微不足道的[a]二烯脱离.
- 从胃 (4-15%) 到大肠液体 (21-29%) 的脱吸增加,因聚合物类型而异.
- 大多数微塑料在小肠液中表现出类似的CRD,除了PA-6变体 (51%释放).
- 微塑料吸收的PAHs对饮食总摄入量的估计贡献非常低 (≤0.1%).
结论:
- 微塑料吸收的PAHs在人体肠道中显示出有限的溶解.
- 聚合物和消化液的类型显著影响PAH释放.
- 微塑料不太可能是饮食中PAH暴露的主要来源.
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