功能双重的抗菌-抗氧化核心/藻酸盐/聚烯) 纳米纤维膜:一个潜在的伤口包裹
Mohammad-Reza Norouzi1,2, Laleh Ghasemi-Mobarakeh2, Fabian Itel1
1Empa, Swiss Federal Laboratories for Materials Science and Technology, Laboratory for Biomimetic Membranes and Textiles, Lerchenfeldstrasse 5, St. Gallen CH-9014, Switzerland.
装有抗生素甘他和抗氧化剂贝林的核心/外纳米纤维将初始药物释放量降至最低. 这些材料表现出抗菌和抗氧化物质的特性,表明有可能用于先进的伤口包裹.
科学领域:
- 生物材料科学 生物材料科学
- 纳米技术 纳米技术
- 药物运输 药物运输 药物运输
背景情况:
- 核心/外纳米纤维使药物的联合递送具有不同的水友性.
- 水友性药物通常会从纳米纤维膜中表现出不良的突发释放.
- 控制释放对于持续的治疗效果至关重要.
研究的目的:
- 开发核心/外纳米纤维,以减轻水友性药物的初始突发释放.
- 创建一个具有抗菌和抗氧化性能的双功能纳米纤维系统.
- 评估开发的纳米纤维的受控释放,抗菌疗效,抗氧化活性和生物相容性.
主要方法:
- 乳液电被用于制造核心/外纳米纤维.
- 甘他素 (水友性抗生素) 被装在一个酸盐核心中.
- 聚甲) (疏水性外) 封装的贝林 (抗氧化剂).
主要成果:
- 纳米纤维成功形成了一个核心/外结构.
- 胺素的释放显著减少 (50%在纳米纤维中相比93%在水凝膜中).
- 观察到显著的抗菌活性对抗阳性和阴性细菌.
- 贝图林表现出抗氧化特性,在20%的负载下,其37.3%的DPPH清理.
- 在细胞培养研究中证实了有利的生物相容性.
结论:
- 核心/外纳米纤维有效控制水友性药物的释放,最大限度地减少爆裂释放.
- 开发的纳米纤维具有结合的抗菌和抗氧化功能.
- 这项技术为先进的伤口带提供了一个有前途的策略,以防止感染和加速愈合.
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