食品化学品和表观遗传标:一个Epi食品化学数据库
K Eurídice Juárez-Mercado1, Juan F Avellaneda-Tamayo1, Hassan Villegas-Quintero1
1DIFACQUIM Research Group. Department of Pharmacy, School of Chemistry, Universidad Nacional Autónoma de México, 04510 Ciudad de México, Mexico.
ACS omega
|June 17, 2024
概括
这项研究引入了Epi食品化学数据库,将食品化学品和天然产品与表观遗传活动联系起来. 它为了解饮食如何影响表观遗传学和疾病提供了宝贵的资源.
科学领域:
- 生物化学 生物化学
- 药理学 药理学是指药理学的学科.
- 生物信息学是一种生物信息学.
背景情况:
- 表观遗传学在疾病病因学和治疗发展方面发挥着至关重要的作用.
- 最近的研究表明,人们对表观遗传过程及其与食品化学物质的联系越来越感兴趣.
- 在全面将食品化学结构与其表观遗传生物活性联系起来的研究中存在差距.
研究的目的:
- 在表观遗传学研究中分析食品化学品和天然产品的现状.
- 量化比较已知表观遗传活性的食品化学品的化学含量,结构多样性和化学空间覆盖.
- 开发具有表观遗传活性的食品和天然产品化学品的精心策划的数据库.
主要方法:
- 利用化学信息学工具进行化学结构和活性的定量比较.
- 建立并策划了一个化合物数据库",Epi食品化学数据库".
- 有注释的化合物具有结构信息,表观遗传目标活性和来源,与FooDB和COCONUT进行交叉链接.
主要成果:
- 建立了与表观遗传学相关的食品和天然产品化学品的综合数据库.
- 定量评估了具有表观遗传活性的食品化学品的化学空间和结构多样性.
- 提供了与主要公共数据库的交叉链接,以提高数据可访问性.
结论:
- "Epi食品化学数据库"为表观遗传学,药理学和营养学研究人员提供了宝贵的资源.
- 这项工作有助于更深入地了解食品成分与表观遗传机制之间的关系.
- 该数据库支持基于表观遗传调节的新疗法和饮食干预措施的开发.
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