使用胆氨基酸离子液体进行水净化:去除阿莫西西林
Pedro Velho1,2, Catarina Lopes1,2, Eugénia A Macedo1,2
1LSRE-LCM-Laboratory of Separation and Reaction Engineering-Laboratory of Catalysis and Materials, Faculty of Engineering, University of Porto, Rua Dr. Roberto Frias, 4200-465 Porto, Portugal.
Industrial & engineering chemistry research
|June 17, 2024
概括
废水中的抗生素残留物构成环境风险. 这项研究探讨了使用环保的水性双相系统与胆氨基酸离子液体进行高效的阿莫西林提取,达到97%的效率.
科学领域:
- 环境化学环境化学
- 绿色化学 绿色化学
- 分离科学 分离科学
背景情况:
- 抗生素对于治疗细菌感染至关重要,但它们的非代谢形式会污染废水,损害水生生态系统并促进抗生素耐药性.
- 传统的废水处理方法难以有效地去除这些持久的制药污染物.
- 水性双相系统 (ATPS) 为提取生物分子和药品提供了一个有前途的,环保的替代方案,因为它们的毒性和能源要求较低.
研究的目的:
- 研究使用胆氨酸离子液体 (CAAILs) 来从水溶液中提取氨基素的新型水性双相系统 (ATPS) 的疗效.
- 评估不同CAAIL和系统参数对阿莫西西林分区的影响.
- 建立一个具有成本效益和对环境无害的方法来从废水中去除阿莫西林.
主要方法:
- 对阿莫西西林的分离研究是在三种由二酸和特定CAAILs ([Ch][Ala],[Ch][Gly],[Ch][Ser]) 在298.15 K和0.1 MPa的ATPS中进行的.
- 分析了pH对阿莫西西林紫外线光谱的影响,以优化量化.
- 计算化学被用来验证合成的离子液体的分子结构.
主要成果:
- 在具有极性较小的离子液体的ATPS中,氨基酸提取效率得到了提高.
- {[Ch][Gly] + K2HPO4 + 水} 系统表现出卓越的性能,达到最大分区系数 (K) 的 (16 ± 6) · 10 ^ 1) 和提取效率 (E) 的97 ± 2%.
- 该研究证实了基于CAAIL的ATPS在有效去除阿莫西林方面的潜力.
结论:
- 基于胆氨基酸离子液体的ATPS在提取阿莫西西林方面非常有效,为传统方法提供了绿色和高效的替代方案.
- 选择离子液极性显著影响提取效率,极性较小的选项产生更好的结果.
- 这项研究提供了一种可持续的方法来减轻废水中的制药污染,保护水生环境并保持抗生素的有效性.
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