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自闭症儿童的口腔微生物群:与诊断相关的差异和与临床特征的关联

Margaux Evenepoel^1,2,3, Nicky Daniels^1,3, Matthijs Moerkerke^3,4

¹KU Leuven, Department of Rehabilitation Sciences, Research Group for Neurorehabilitation, Leuven, Belgium.

Brain, behavior, & immunity - health

|June 17, 2024

概括

口腔微生物组在自闭症儿童中显著不同,特定的细菌与社会困难和焦虑有关. 这些发现表明,口腔微生物组可能会影响自闭症.

科学领域:

微生物学微生物学
神经科学是一个神经科学.
遗传学遗传学是一个

背景情况:

口腔微生物组在自闭症病因学中的作用尚未得到充分研究.
了解口腔微生物组的变化及其与自闭症临床特征的联系至关重要.
诸如口腔健康和营养等生活方式因素对这些关联的影响在很大程度上是未知的.

研究的目的:

调查自闭症和典型发育儿童口腔微生物组合的差异.
探索口腔微生物组变异与自闭症相关行为 (社会功能,重复性行为,焦虑) 之间的关联.
评估生活方式变量对这些口腔微生物组与自闭症相关性的影响.

主要方法:

在80名自闭症儿童和40名典型发育儿童 (8-12岁) 中,比较了口腔微生物组组成.
评估了与社会功能 (SRS-2),重复行为 (RBS-R) 和焦虑 (SCARED) 的关联.
对生活方式变量进行控制,包括营养和口腔健康.

主要成果:

自闭症儿童的细菌属数量显著增加: *Solobacterium*, *Stomatobaculum*, *Ruminococcaceae UCG.014*, *Tannerella* 和 *Campylobacter*.
其中四个属 (*Solobacterium*, *Stomatobaculum*, *Ruminococcaceae UCG.014*, *Tannerella*) 与社会困难,重复行为和焦虑有显著的相关性.
生活方式变量没有显著地驱动口腔微生物组和自闭症特征之间的观察到的关联.

结论:

自闭症和非自闭症儿童之间存在口腔微生物组合的显著差异.
口腔微生物组的变异可能与自闭症的临床表现有关,包括社会和行为方面.
需要进一步的研究来了解口腔微生物组在口腔外的神经精神疾病中的作用.

关键词:

自闭症谱系障碍自闭症谱系障碍微生物学微生物学儿科人口中的儿童.精神病学是一个精神病学.

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