范科米辛和塞福塔克西姆结合的全蚀刻粘合系统的抗菌活性 - 一个体外研究
M S Rangareddy1, Md Abdul Wahed2, B Shravan Kumar1
1Department of Conservative Dentistry and Endodontics, Panineeya Institute of Dental Sciences and Research Centre, Kaloji Narayana Rao University of Health Sciences, Warangal, Telangana, India.
Journal of pharmacy & bioallied sciences
|June 17, 2024
概括
与Cefotaxime相比,结合Vancomycin的抗菌结合剂对Streptococcus mutans显示出更高的疗效. 这项研究通过增强牙粘合系统来解决二次和过敏症.
科学领域:
- 牙科材料科学 牙科材料科学
- 微生物学 微生物学
- 皮肤病学 皮肤病学 皮肤病学
背景情况:
- 树脂-牙接口的边缘失效可能导致生物膜形成,二次,以及过敏.
- 洞穴后准备的残留细菌加剧了这些问题.
- 具有抗菌性能的粘合剂系统的功能化旨在在不损害粘合强度的情况下实现生物密封.
研究的目的:
- 为了评估一个全蚀刻粘合剂系统对Streptococcus mutans的抗菌活性.
- 为了比较范科米辛和塞福塔克西姆在加入粘合剂系统时的疗效.
主要方法:
- 使用的是第五代全蚀刻粘合剂.
- 突变性链球菌的培养是在穆勒-欣顿基上培养的.
- 含有Cefotaxime,Vancomycin,单独的粘合剂或组合的井被评估为抑制区域.
主要成果:
- 跨组观察到抑制区域的统计学上显著差异 (p=0.000).
- 范科米辛和结合剂的组合显示出最大的抑制区域.
- 塞福胺和结合剂组合的抑制作用低于万科米辛组的抑制作用.
结论:
- 与含有Cefotaxime的药物相比,含Vancomycin的结合剂对Streptococcus mutans具有更高的抗菌活性.
- 将抗生素纳入粘合剂系统是一个可行的策略,以应对树脂-牙接口上的细菌挑战.
相关概念视频
01:28Antimicrobial Effectiveness
2.3K
The effectiveness of antimicrobial agents depends on various factors influencing their ability to eliminate microbial populations. Larger microbial populations require more time for complete eradication, emphasizing the importance of population size analysis when evaluating antimicrobial efficacy.Microbial resistance to antimicrobial agents varies significantly. Highly resilient microorganisms include endospores, gram-negative bacteria, and non-enveloped viruses, while prions are exceptionally...
2.3K
01:23Inhibitors of Gram-positive Cell Wall Synthesis
191
Bacterial cell walls are typically rigid structures composed mainly of peptidoglycan, a mesh-like polymer that provides mechanical strength and maintains cell shape. The synthesis of peptidoglycan is a crucial process in bacterial growth and serves as a primary target for many antibiotics.Mechanism of Action of Beta-Lactam AntibioticsBeta-lactam antibiotics, such as penicillin, inhibit peptidoglycan synthesis in actively growing cells. These antibiotics share a characteristic four-membered...
191