患有阻塞性睡眠呼吸暂停的患者的外周血液免疫细胞的差异和危险因素
Ying Jiang1, Chuankai Lin1, Min Xu2
1Department of Respiratory and Critical Care Medicine, Zhongnan Hospital of Wuhan University, Wuhan, 430071, People's Republic of China.
阻塞性睡眠呼吸暂停 (OSA) 增加了周围血液单细胞计数. 呼吸暂停-呼吸暂停指数,COPD,吸烟和心率是关键的危险因素,这表明单细胞是OSA的炎症生物标志物.
科学领域:
- 呼吸系统医学 呼吸系统医学
- 免疫学 免疫学 免疫学
- 睡眠医学 睡眠医学
背景情况:
- 阻塞性睡眠呼吸暂停 (OSA) 涉及间歇性缺氧和睡眠碎片化,引发炎症和氧化应激.
- 在OSA患者中,免疫反应因严重程度而异,但具体差异尚不清楚.
研究的目的:
- 在OSA患者中调查周围血液免疫细胞的差异.
- 为了确定与OSA免疫细胞变化相关的风险因素.
主要方法:
- 招募了277名打患者,将他们分为简单的打,轻度,中度和严重的OSA组.
- 收集的外周血液免疫细胞计数 (WBC,中性粒细胞,淋巴细胞,单细胞,氨基细胞,基细胞) 和多睡眠学数据.
主要成果:
- 与简单的打者相比,OSA患者的单细胞和基细胞数量增加.
- 单细胞计数与COPD,吸烟,呼吸暂停-呼吸暂停指数 (AHI),呼吸暂停持续时间最长和氧气不和指数 (ODI) 有积极的相关性.
- AHI,COPD,吸烟和最大心率被确定为单细胞计数的独立预测因素.
结论:
- 阻塞性睡眠呼吸暂停与周围血液单细胞数显著增加有关.
- 单细胞升高的主要危险因素包括AHI,COPD,吸烟和最大心率.
- 周围血液单细胞可以作为OSA的有价值的炎症生物标志物.
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