胃肠外科手术后的胃肠透性:一个系统性审查
James W O'Brien1,2, Nabeel Merali1,2, Chris Pring3
1Department of Surgery, School of Biosciences and Medicine, University of Surrey, Guildford, GBR.
Cureus
|June 17, 2024
概括
腹腔外科手术是什么意思
科学领域:
- 胃肠道生理学 胃肠道生理学
- 代谢性疾病研究研究.
- 外科手术的结果
背景情况:
- 胃肠透性,即物质穿过肠壁的运动,与内毒性和代谢性疾病有关.
- 减肥手术对肠道透性的影响尚不清楚,体重,饮食和代谢变化可能会对其产生影响.
研究的目的:
- 系统地审查和分析关于减肥手术对胃肠道通透性的影响的现有证据.
主要方法:
- 通过使用MEDLINE,EMBASE和Scopus数据库进行了系统审查,直到2023年2月.
- 搜索术语包括"肠道透性"和"腹腔".
- 包括在体内报告的透性评估研究;确定了三个队列研究和两个病例系列 (n=96).
主要成果:
- 在袖子胃切除术 (SG) 后,胃肠透性下降.
- 小肠透性在胆腺转移后增加,但在Roux-en-Y胃绕道后降低.
- 结肠透性在SG后六个月增加,引发了对蛋白质发酵的担忧.
结论:
- 关于减肥手术对胃肠透性的影响的证据是相互矛盾的,特别是对于小肠.
- 在SG后增加的结肠透性需要进一步调查潜在的负面饮食后果.
- 包括手术程序,微生物群和代谢反应在内的多个因素影响了透性变化,需要进一步研究.
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