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周产期A组阴道链球菌感染及其对怀孕结果的影响
Min Song1, Xiaoge Huang1, Yanmei Hou1
1Department of Obstetrics and Gynecology, Jinan Maternal and Child Health Hospital Affiliated to Shandong First Medical University Jinan, Shandong, China.
American journal of translational research
|June 17, 2024
概括
孕妇的A组链球菌 (GAS) 阴道感染与不良结果有关. 更高的阴道pH值和微生态失衡增加了母亲和婴儿的风险,尽管没有发现β-乳抗性.
科学领域:
- 产科和妇科 产科和妇科
- 传染性疾病 传染性疾病
- 微生物学 微生物学
背景情况:
- 围产期妇女的A组链球菌 (GAS) 阴道殖民是令人担忧的.
- 了解GAS对怀孕和新生儿后果的影响至关重要.
研究的目的:
- 为了确定阴道GAS在围产妇女的流行率和抗菌素敏感性.
- 调查GAS感染,阴道微生态和不良怀孕/新生儿结果之间的关联.
主要方法:
- 从270名孕期妇女收集了阴道拭子,用于GAS培养和抗生素敏感性测试.
- 女性根据GAS状态 (阳性/阴性) 进行分组,对阴道微生态和怀孕/婴儿结果进行比较分析.
- 单变量和多变量分析确定了不良结果的风险因素.
主要成果:
- 观察到的GAS殖民率为11.1%.
- 没有发现对青素等关键抗生素的耐药性;然而,注意到对四环素 (73.3%) 和克林达胺素 (70.0%) 的高耐药性.
- GAS阳性女性的阴道pH值较高,细菌性阴道炎和有氧性阴道炎的发病率增加,不良结果的发病率更高,包括膜炎,产后感染,胎儿痛苦和新生儿肺炎.
结论:
- 在这个队列中,没有发现抗β-乳酸的GAS菌株.
- 阴道pH值升高 (≥4.5) 和阴道微生态不平衡是患有GAS感染的女性对孕产妇和婴儿不良后果的重要危险因素.
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