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各种干预措施对预防辐射皮肤炎的影响:一个网络元分析

Hongxin Cao^1,2, Wangbin Li², Hongyi Cai³

¹The First Clinical Medical College of Gansu University of Chinese Medicine No. 35 Dingxi East Road, Chengguan District, Lanzhou 730000, Gansu, China.

American journal of translational research

|June 17, 2024

概括

氨酸奶油和橄油和氧化 (OOCH) 在癌症放射治疗期间有望预防辐射皮炎 (RD). 这些干预措施为管理这种常见且可能严重的副作用提供了有效的策略.

科学领域:

在瘤学瘤学.
皮肤病学皮肤病学
辐射疗法辐射疗法

背景情况:

放射性皮肤炎 (RD) 是癌症放射治疗的常见并发症,影响患者的生活质量和治疗疗效.
目前的临床实践缺乏用于RD预防和管理的标准化协议.
有效的干预措施对于减轻放射治疗的不良影响至关重要.

研究的目的:

进行系统审查和网络元分析 (NMA),比较各种干预措施预防RD的有效性.
确定在接受放射治疗的患者中预防RD的最佳策略.

主要方法:

在PubMed,Embase,Web of Science和Cochrane图书馆数据库中进行了全面的搜索,截至2023年6月.
使用贝叶斯网络元分析 (NMA) 分析了19项干预措施,其中包括StataSE 15和R 4.2.3.3.
考克伦偏差风险工具用于研究选,数据提取和质量评估.

主要成果:

总共有33项涉及4307名患者的研究被纳入分析.
氨酸奶油在预防0/1级RD方面表现出高效率 (SUCRA:94.9%).
橄油和氧化 (OOCH) 在预防2级或以上的RD方面表现最为显著 (SUCRA:95.7%).

结论:

氨酸奶油和OOCH成为预防辐射皮肤炎的高效治疗方法.
这些发现表明,对于接受放射治疗的患者来说,有前途的治疗选择.
建议使用更大的样本大小进行进一步的研究,以验证疗效并优化干预策略.

关键词:

辐射皮肤炎是一种辐射皮肤炎.临床疗效临床疗效网络元分析网络元分析辐射疗法辐射疗法专题干预措施专题干预

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