在接受术后化疗的胃癌患者中,血红蛋白下降的危险因素:回顾性分析
Ruofei Ma1, Huqin Yuan1, Yaling Wang2
1Department of Gastric Tumor Surgery, Gansu Provincial Cancer Hospital, Gansu Provincial Academic Institute for Medical Research No. 2 Xiaoxihu East Street, Qilihe District, Lanzhou 730050, Gansu, China.
American journal of translational research
|June 17, 2024
概括
化疗期间胃癌患者血红蛋白降低的关键因素包括手术期间出血,化疗前贫血和低albuminemia. 这些发现有助于管理化疗诱导的贫血.
科学领域:
- 在瘤学瘤学.
- 血液学 血液学 血液学
- 临床研究 临床研究
背景情况:
- 接受辅助化疗的胃癌患者容易出现血红蛋白水平下降的情况.
- 贫血会对治疗结果和生活质量产生负面影响.
研究的目的:
- 在接受辅助化疗的胃癌患者中,确定与降低血红蛋白水平相关的独立风险因素.
- 为在治疗期间主动管理贫血提供见解.
主要方法:
- 一项对142名接受白金/太和甲化疗的胃癌患者的回顾性研究.
- 使用后勤和LASSO回归分析来确定独立的风险因素.
- 开发了一个名ogram模型,并进行了内部验证.
主要成果:
- 单变和回归分析确定了手术期间出血,化疗前贫血和低蛋白血是降低血红蛋白的重要危险因素.
- 后勤和LASSO回归模型在识别这些因素方面表现相似.
- 随着满意的校准,诺莫格拉姆模型实现了0.712的C指数.
结论:
- 术内流血,化疗前贫血和低蛋白血是胃癌化疗期间血红蛋白减少的独立预测因素.
- 这些已识别的风险因素可以指导临床策略,在这个患者群体中治疗贫血.
- 该研究强调了监测和解决这些因素的重要性,以优化患者护理.
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