综合的泛癌分析显示,VSIR是候选免疫学,诊断和预后生物标志物
Jun Pan1, Ihsanullah Mahsud2, Moeen Ul Haq3
1Department of Thoracic Surgery/Cardiovascular Surgery, The First People's Hospital of Xiaoshan District, Xiaoshan Affiliated Hospital of Wenzhou Medical University Hangzhou 311200, Zhejiang, China.
American journal of translational research
|June 17, 2024
概括
在不同癌症中,V-集免疫调节受体 (VSIR) 的表达有所不同,影响食道癌和肝癌的存活率. 这项研究揭示了VSIR.
科学领域:
- 在瘤学瘤学.
- 免疫学 免疫学 免疫学
- 基因组学就是基因组学.
背景情况:
- V集免疫调节受体 (VSIR) 作为一个检查点,其表达水平表明免疫抑制程度.
- 了解VSIR的作用对于开发向癌症免疫疗法至关重要.
研究的目的:
- 进行VSIR表达,遗传变化,预后价值和免疫学关联的泛癌分析.
- 调查VSIR在瘤发生中的作用及其与瘤微环境特征的相关性.
主要方法:
- 利用癌症基因组图集 (TCGA) 和基因型-组织表达 (GTEx) 数据库进行全面分析.
- 使用生物信息学工具 (GEPIA2,UALCAN,OncoDB) 进行表达,改变和生存分析.
- 通过细胞培养,临床样本采集和RT-qPCR验证的发现.
主要成果:
- 在胆管癌,食道癌 (ESCA),脏细胞癌和肝肝细胞癌 (LIHC) 中,VSIR表达显著升高.
- 较高的VSIR表达与ESCA和LIHC的总生存率降低相关,并且与晚期癌症阶段有关.
- VSIR表达与免疫细胞透正相关,并显示与瘤突变负担 (TMB) 和微卫星不稳定性 (MSI) 的关联.
结论:
- 在各种癌症,特别是ESCA和LIHC中,VSIR起着多样化和潜在的致癌作用.
- 结果强调VSIR作为一种潜在的预后生物标志物和特定癌症类型的治疗点.
相关概念视频
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Pancreatitis is inflammation of the pancreas, an organ located behind the stomach. It can be either acute or chronic.
Acute pancreatitis is characterized by rapid inflammation of the pancreas, often caused by factors like gallstone blockage or excessive alcohol consumption. Chronic pancreatitis, on the other hand, is a slow, progressive inflammation that may result from long-term alcohol abuse, obstructions in the pancreatic duct, or genetic factors.
The causes of acute pancreatitis include:
Acute pancreatitis is characterized by rapid inflammation of the pancreas, often caused by factors like gallstone blockage or excessive alcohol consumption. Chronic pancreatitis, on the other hand, is a slow, progressive inflammation that may result from long-term alcohol abuse, obstructions in the pancreatic duct, or genetic factors.
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Pancreatitis is the inflammation of the pancreas, which occurs when the immune system becomes active and causes swelling, pain, and disruptions in organ function. Pancreatitis can manifest as either an acute or chronic condition.
Acute pancreatitis arises suddenly and lasts for a brief duration, while chronic pancreatitis is a long-term affliction...
Pancreatitis is the inflammation of the pancreas, which occurs when the immune system becomes active and causes swelling, pain, and disruptions in organ function. Pancreatitis can manifest as either an acute or chronic condition.
Acute pancreatitis arises suddenly and lasts for a brief duration, while chronic pancreatitis is a long-term affliction...
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