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优化针对膜蛋白标的基于NMR片段的药物查

Geoffrey C Li1, Manuel A Castro1, Thilini Ukwaththage1

  • 1Department of Biochemistry and Center for Structural Biology, Vanderbilt University School of Medicine - Basic Sciences, Nashville, TN 37240, USA.

Journal of structural biology: X
|June 17, 2024
PubMed
概括

核磁共振 (NMR) 光谱现在可以基于碎片对膜蛋白进行查,这对于药物发现至关重要. 这种新方法成功地确定了针对人类膜蛋白的潜在药物化合物.

关键词:
粉样蛋白前体蛋白是一种前体蛋白.C9999 C9999 是一个字母.在FBDD和FBDD之间.基于碎片的药物发现.基于碎片的查是基于碎片的查.膜蛋白是一种膜蛋白质.核磁共振光谱法 (NMR) 是一种光谱法.在PMP2222中使用.周边髓蛋白 22 周边髓蛋白 22蛋白质-小分子相互作用

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