在骨质疏松症中miRNA调节型H血管形成的作用
Dailiang Zhang1, Yongjing Wang1, Zunzhen Zhou1
1Clinical Medical College and the First Affiliated Hospital of Chengdu Medical College, Chengdu, Sichuan, China.
Frontiers in endocrinology
|June 17, 2024
概括
微RNAs (miRNAs) 通过调节称为H型血管的独特骨微血管来影响骨质疏松症. 了解这种联系为骨质疏松症治疗提供了新的治疗策略.
科学领域:
- 骨生物学 骨生物学
- 血管生物学 血管生物学
- 分子遗传学 分子遗传学
背景情况:
- 骨质疏松症 (OP) 是一种与衰老相关的流行骨代谢疾病,其特点是骨质减少和骨折风险增加.
- 类型H血管,独特的骨微血管对于骨质生成-血管生成合至关重要,越来越多地被认可为其在OP病变发生中的作用.
- 微RNAs (miRNAs) 正在成为包括OP在内的各种疾病的关键调节者,促使人们对它们的特定作用进行调查.
研究的目的:
- 审查H型血管在骨质疏松病原发生中的作用.
- 探索miRNAs如何调节H型血管形成.
- 为OP提供基于miRNA介导的H型血管调节的新型治疗方法的见解.
主要方法:
- 文献综述侧重于miRNAs,H型血管和骨质疏松症之间的相互作用.
- 对参与H型血管形成的关键因素的miRNA调节现有研究的分析,如PDGF-BB,HIF-1α和VEGF.
主要成果:
- H型血管对于保持骨健康至关重要,并与OP发展有关.
- 已经确定了特定的miRNAs调节H型血管的形成和功能.
- 这些miRNA通过向血管生成和骨质生成所必需的调节因素来发挥其作用.
结论:
- 通过对H型血管形成的控制,MiRNAs代表了骨质疏松症病变的重要调节层.
- 针对参与H型血管调节的miRNA通路,为开发有效的骨质疏松症治疗提供了一个有希望的新途径.
相关概念视频
Regulation of Angiogenesis and Blood Supply
2.5K
Rapidly dividing tumors, embryos, and wounded tissues require more oxygen than usual, lowering the oxygen concentration in the blood. At low oxygen or hypoxic conditions, an oxygen-sensitive transcription factor called the hypoxia-inducible factor 1 or HIF1 is activated. HIF1 is a dimeric protein of alpha (ɑ) and beta (β) subunits. Under optimal oxygen conditions, HIF1β is present in the nucleus while HIF1ɑ remains in the cytosol. HIF1ɑ is hydroxylated by prolyl...
2.5K
MicroRNAs
3.0K
MicroRNA (miRNA) are short, regulatory RNA transcribed from introns (non-coding regions of a gene) or intergenic regions (stretches of DNA present between genes). Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself, forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA...
3.0K
Bone Remodeling
38.3K
Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.
38.3K
Osteoclasts in Bone Remodeling
2.9K
Osteoclasts are cells responsible for bone resorption and remodeling. They originate from hematopoietic progenitor cells present in the bone marrow. Numerous progenitor cells fuse to form multinucleated cells, each with 10-20 nuclei. A single osteoclast has a diameter of 150 to 200 µM. These cells have ruffled borders that break down the underlying bone tissue and release minerals such as calcium into the blood in bone resorption. Osteoclasts cling to bones with their ruffled edges during...
2.9K
Role of Vitamins in Maintaining Bone Health
3.2K
The growth and maintenance of bone are regulated by a combination of nutritional factors, including vitamins, such as vitamin A, B12, C, D, and K.
Vitamin A
Vitamin A is involved in the process of bone remodeling. Retinoic acid, the active metabolite of Vitamin A, has nuclear receptors in osteoblasts and osteoclasts, which are involved in bone remodeling.
Vitamin B12
Vitamin B12 acts as a cofactor during the formation of osteoblast-related proteins, such as osteocalcin. Vitamin B12 plays a role...
Vitamin A
Vitamin A is involved in the process of bone remodeling. Retinoic acid, the active metabolite of Vitamin A, has nuclear receptors in osteoblasts and osteoclasts, which are involved in bone remodeling.
Vitamin B12
Vitamin B12 acts as a cofactor during the formation of osteoblast-related proteins, such as osteocalcin. Vitamin B12 plays a role...
3.2K
Bone Disorders
3.5K
Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
3.5K


