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营养状况及其与孕妇和新生儿TSH甲状腺功能的关联
Lijun Fan1,2,3, Ye Bu4, Shiqi Chen1
1Endemic Disease Control Center, Chinese Center for Disease Control and Prevention, Harbin Medical University, Harbin, China.
Frontiers in endocrinology
|June 17, 2024
概括
孕妇的状况会影响甲状腺功能和怀孕期间的疾病. 新生儿甲状腺刺激激素 (TSH) 受母亲TSH的影响,血清度 (SIC) 是一个关键指标.
科学领域:
- 内分泌学 在内分泌学.
- 营养科学 营养科学
- 孕产妇和胎儿医学 孕产妇和胎儿医学
背景情况:
- 对于甲状腺激素的合成至关重要,对母亲和胎儿的健康至关重要.
- 状态,母体甲状腺功能和充足地区新生儿结果之间的确切关系需要进一步澄清.
研究的目的:
- 调查营养状况,孕妇甲状腺功能和孕妇新生儿结局之间的相关性.
- 确定最佳的摄入范围,以尽量减少孕妇甲状腺疾病.
主要方法:
- 收集了559名孕妇的血液,早晨尿液和24小时尿液,以评估甲状腺功能和状态 (血清度[SIC],尿液度[UIC],24小时尿液分泌[24小时UIE]).
- 记录的新生儿结果指标和甲状腺刺激激素 (TSH) 水平.
主要成果:
- 指标在甲状腺和甲状腺乱的孕妇之间有显著差异.
- 血清度 (SIC) 显著影响了母亲的自由甲状腺素 (FT4) 水平,特别是在第二和第三个三个月,而TSH是第一个三个月的主要决定因素.
- 为了减少甲状腺疾病,确定了最佳的摄入范围,母亲的TSH影响了新生儿的TSH水平.
结论:
- 孕产妇的营养状况会影响甲状腺功能和甲状腺疾病的发生率.
- 血清度 (SIC) 可能是怀孕期间营养状况的更可靠指标,而不是其他生物标志物.
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