我的细菌 gordonae:煤矿中的金丝雀?
Daniel Condit1, Lori Avery2, Charles L Daley3
1Division of Pulmonary, Critical Care and Sleep Medicine, University of Connecticut School of Medicine, Farmington, CT, USA.
Journal of thoracic disease
|June 17, 2024
概括
隔离Mycobacterium gordonae (M. gordonae) 在支气管切除症患者中更为常见. 这一发现表明,M. gordonae可能表明潜在的呼吸道疾病以及其他非结核菌根 (NTM) 感染的风险更高.
科学领域:
- 肺部病理学 肺部病理学
- 传染性疾病 传染性疾病
- 微生物学 微生物学
背景情况:
- 非结核菌 (NTM) 很少引起感染,而 Mycobacterium gordonae (M. gordonae) 是一个常见的污染物.
- 气管扩张的支气管病,增加了由致病性NTM如Mycobacterium avium complex (MAC) 和Mycobacterium abscessus (M. abscessus) 引起的肺部疾病的风险.
- 支气管切除症与不太致病性NTM (如M. gordonae) 之间的关联尚不清楚.
研究的目的:
- 为了研究M. gordonae隔离和支气管切除之间的关系.
- 确定M. gordonae的隔离是否与患有支气管切除症的患者感染更致病性NTM物种的风险增加有关.
主要方法:
- 追溯研究分析了UConn健康分离的M. gordonae患者的呼吸器样本 (2010年5月 - 2022年10月).
- 在有和没有支气管切除症的患者之间比较M. gordonae隔离率.
- 对与M. gordonae相关的致病性NTM物种 (MAC,M. abscessus) 的同时或随后隔离的分析.
主要成果:
- 在56名患者中,M. gordonae被隔离了74次;31名患者患有支气管切除症.
- 支气管切除症患者的M. gordonae隔离概率显著增加 (4.3%对1.6%,P=0.007),患者隔离率增加 (7.1%对2.2%,P<0.001).
- 在支气管切开症患者中观察到病原性NTM (MAC,M.) 的隔离增加的非统计学意义上的趋势 (P=0.09) (45.2%对29%).
结论:
- 隔离M. gordonae应该引起对潜在的慢性呼吸道疾病的怀疑,例如支气管病,以及潜在的宿主免疫缺陷.
- 隔离M. gordonae可能是感染更致病性NTM物种的风险增加的指标,包括MAC和M. abscessus.
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