在胸壁切除后,胸腔重塑和肺功能变化
Seon Yong Bae1, Ji Hyeon Park1, Bubse Na1
1Department of Thoracic and Cardiovascular Surgery, Seoul National University Hospital, Seoul, Republic of Korea.
Journal of thoracic disease
|June 17, 2024
概括
胸壁切除 (CWR) 显著降低了长期的肺功能,特别是强迫活力和FEV1,特别是在切除三个或更多肋骨后. 胸腔体积变化与这些肺功能下降没有相关性.
科学领域:
- 胸部外科手术 胸部外科手术
- 肺部医学 肺部医学
- 医疗成像医学成像
背景情况:
- 胸壁切除 (CWR) 对于治疗胸壁恶性瘤和感染至关重要.
- 关于CWR对肺功能和胸腔体积 (TCV) 的影响的研究有限.
研究的目的:
- 研究CWR对TCV和肺功能的长期影响.
- 在CWR后一年分析TCV和肺功能的变化.
主要方法:
- 在2001-2021年期间接受CWR的45名患者的回顾性审查.
- 排除单个肋骨或切割的患者.
- 通过CT扫描测量TCV;分析肺功能测试 (FVC,FEV1,DLCO).
主要成果:
- 在CWR后,FVC (-7.9%) 和FEV1 (-7.0%) 的长期显著下降.
- 在FEV1/FVC比率,DLCO或整体TCV中没有显著变化.
- 切割≥3个肋骨导致FVC,FEV1和TCV的显著下降.
- 在TCV变化和肺功能下降之间没有发现相关性.
结论:
- CWR导致显著的长期肺功能障碍.
- 损伤的程度在切割三个或更多肋骨时更大.
- TCV 变化与观察到的肺功能缺陷没有直接关联.
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