肯塔基州废水监测Xylazine 在肯塔基州的废水监测
Chris Delcher1, Dana Quesinberry2, Soroosh Torabi3
1Institute for Pharmaceutical Outcomes and Policy, College of Pharmacy, University of Kentucky, Lexington, Kentucky.
AJPM focus
|June 17, 2024
概括
肯塔基州的废水测试检测到超过60%的样本中含有危险药物西拉. 尽管广泛检测,但报告的过量死亡人数仍然很低,这表明需要进一步调查和有针对性的减少危害.
科学领域:
- 环境科学环境科学
- 公共卫生 公共卫生
- 法医毒理学 法医毒理学
背景情况:
- 施拉是一种兽医镇静剂,在美国的非法药物供应中越来越多地检测到.
- 它的存在对公众健康构成重大威胁,特别是在与芬太尼混合时.
- 了解它的分布对于有效的公共卫生干预至关重要.
研究的目的:
- 为了比较废水检测的西拉与公众健康和安全监测数据在肯塔基州从2019年到2023年.
- 评估西拉暴露的地理分布和趋势.
- 评估基于废水的药物监测的实用性.
主要方法:
- 从道路站点和废水处理厂收集废水样本.
- 在废水中检测到的西拉与国家法医实验室信息系统的数据和致命过量报告进行了比较.
- 从2019年到2023年6个月的时间段分析了数据.
主要成果:
- 在61.6%的每日废水样本中检测到西拉,道路站点的检测率从2021年的55%增加到2023年的94%.
- 在法医数据中,废水检测与增加的克西拉阳性提交相关.
- 虽然废水表明了广泛的暴露,但肯塔基州报告的致死性过量服用西拉的数量与其他州相比显著低.
结论:
- 基于废水的监测有效地表明肯塔基州广泛暴露于克西拉.
- 废水数据和报告的健康结果之间的差异需要进一步调查.
- 调查结果支持将基于废水的药物监测纳入公共卫生战略,并表明需要在运输路线上有针对性的减少危害.
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