脑和身体健康的多器官成像衍生的多基因指数
Xiaochen Yang1, Patrick F Sullivan2, Bingxuan Li3
1Department of Statistics, Purdue University, West Lafayette, IN 47907, USA.
medRxiv : the preprint server for health sciences
|June 17, 2024
概括
遗传分数预测可遗传的成像特征,在较大群体中识别疾病风险. 这种方法超越了传统方法,为大脑和身体状况提供了新的见解.
科学领域:
- 遗传学 是一个遗传学.
- 生物医学研究生物医学研究
- 医疗成像医学成像
背景情况:
- 英国生物银行 (UKB) 的成像项目是一个有价值的资源,但仅限于10万名参与者.
- 成本和可访问性是扩大UKB成像队伍的障碍.
研究的目的:
- 使用遗传数据预测可遗传的成像衍生的表型 (IDP) 对一个更大的队列.
- 评估IDP遗传分数 (IGS) 对疾病风险分层的有用性.
主要方法:
- 从UKB的大脑和身体图像开发和评估了4,375个IDP遗传分数 (IGS).
- 应用IGS给不包括在成像队列中的UKB参与者.
- 将IGS应用于独立的外部队列:我们所有人的研究计划和ADNI研究.
主要成果:
- IGS揭示了无图像UKB参与者的许多表型的联系.
- IGS确定了患有阿尔茨海默氏症和多发性硬化症等脑疾病风险增加的个体.
- 在外部队列中,IGS成功地分层了高疾病风险,证明了广泛的适用性.
结论:
- IGS可以预测遗传性成像表型,并在较大人群中分层疾病风险.
- 国际基因系统为传统的多基因风险评分提供了补充的洞察力.
- 虽然UKB成像队列健康,但在外部遗传队列中存在风险分层的潜力.
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