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Updated: Jun 23, 2025

In Vitro SUMOylation Assay to Study SUMO E3 Ligase Activity
09:45

In Vitro SUMOylation Assay to Study SUMO E3 Ligase Activity

Published on: January 29, 2018

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SUMOylation的向导致cBAF复杂的稳定和破坏SS18::SSX转录组在Synovial Sarcoma中的转录组

Konstantinos V Floros1,2, Carter K Fairchild1,3, Jinxiu Li4

  • 1VCU Philips Institute, Virginia Commonwealth University School of Dentistry and Massey Comprehensive Cancer Center, Richmond VA, 23298 USA.

Research square
|June 17, 2024
PubMed
概括

突肉瘤是由SS18::SSX驱动的,它破坏了染色质重塑. 用TAK-981向SUMOylation通路恢复正常的复合体,抑制瘤生长,并提高化疗的疗效.

关键词:
在BAF复合体中,BAF复合体造成的DNA损伤是DNA损伤.这就是SUMOylation的作用.在 SWI/SNF 中.我们的TAK-981号.突性肉瘤 (Synovial Sarcoma) 是一个突性肉瘤.有针对性的治疗.

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