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Updated: Jun 20, 2026

Chromatin Immunoprecipitation Assay for Tissue-specific Genes using Early-stage Mouse Embryos
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Chromatin Immunoprecipitation Assay for Tissue-specific Genes using Early-stage Mouse Embryos

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胚胎小鼠腹膜肌中的空间转录学揭示了发育基因表达的区域梯度和子域

Mehmet Mahsum Kaplan1, Maximilian Zeidler1, Annabella Knapp2

  • 1Institute of Physiology, Medical University Innsbruck, 6020 Innsbruck, Austria.

iScience
|June 17, 2024
PubMed
概括

这项研究绘制了胚胎小鼠腹膜中的基因表达图,揭示了与肌肉发育和神经肌肉结 (NMJ) 形成相关的空间模式. 它确定了对隔膜发育和NMJ组装至关重要的关键基因.

关键词:
发育生物学是发展生物学.模型生物模型生物.分子生理学分子生理学文字转录学 (Transcriptomics) 是一个学科.

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Gastrulation01:56

Gastrulation

Gastrulation establishes the three primary tissues of an embryo: the ectoderm, mesoderm, and endoderm. This developmental process relies on a series of intricate cellular movements, which in humans transforms a flat, “bilaminar disc” composed of two cell sheets into a three-tiered structure. In the resulting embryo, the endoderm serves as the bottom layer, and stacked directly above it is the intermediate mesoderm, and then the uppermost ectoderm. Respectively, these tissue strata will form...