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在多发性硬化症患者群体中,哪个临床参数强烈地将白质管道变化与排泄功能障碍联系在一起? 一个前性的探索性研究
C Mazeaud1,2, Darshil Choksi3, Khue Tran1
1Houston Methodist Hospital, Department of Urology, Houston, Texas, USA.
JU open plus
|June 17, 2024
概括
在多发性硬化症 (MS) 中,空虚后残留体积 (%PVR/BV) 与白质变化和疾病进展相关,为监测下尿路症状的MS患者提供了客观的衡量标准.
科学领域:
- 神经成像是一种神经成像.
- 泌尿器科 泌尿器科 泌尿器科 泌尿器科
- 神经学 神经学
背景情况:
- 下尿道症状 (LUTS) 在多发性硬化症 (MS) 中很常见,随着疾病的进展而恶化.
- 通过扩散张力成像 (DTI) 评估的白质完整性变化也是MS的特征.
- 了解临床LUTS参数与白质结构之间的相关性对于监测MS至关重要.
研究的目的:
- 为了将多发性硬化患者的临床和泌尿动力学参数与扩大残疾状态量表 (EDSS) 和白质完整性 (DTI) 的LUTS相关联.
- 确定哪些LUTS参数最能与白质中的结构变化相关.
主要方法:
- 十名患有稳定多发性硬化和排泄功能障碍的成年女性 (PVR/BV%>20%) 接受了尿动力学研究 (UDS) 和DTI MRI.
- 分析了DTI数据以提取分数异构性 (FA) 和平均扩散性 (MD).
- 皮尔森的相关性测试了白质完整性 (WMT) 参数,临床数据和EDSS分数之间的关联.
主要成果:
- %PVR/BV参数与所有临床参数中最多的WMTs有显著的相关性.
- %PVR/BV是唯一与EDSS得分显著相关的临床参数.
- 这些发现表明%PVR/BV作为MS进展的潜在客观标志物.
结论:
- 虚后残留体积 (%PVR/BV) 可以作为一个客观参数来评估MS患者的白质变化和疾病进展.
- 这一参数可能有助于监测多发性硬化症的进展,特别是在患有LUTS的患者中.
- 需要进一步的研究来验证和完善这种预测模型.
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