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微泡作为本地药物输送系统在内牙治疗中的作用 - - 一项实验室研究

V Shyam Ganesh¹, K Vijay Venkatesh¹, D Sihivahanan¹

¹Department of Conservative Dentistry and Endodontics, SRM Kattankulathur Dental College and Hospital, SRM Institute of Science and Technology, Kattankulathur, Tamil Nadu 603203, India.

The Saudi dental journal

|June 17, 2024

概括

微气泡 (MBs) 通过显著提高对Enterococcus faecalis的抗菌疗效来增强内治疗. 这种新的本地药物输送系统显示出更好的根管消毒的希望.

科学领域:

纳米医学是一种纳米医学.
生物技术是生物技术.
微生物学微生物学

背景情况:

微气泡 (MB) 是有前途的纳米医学工具,因为其高封装效率,有针对性的药物释放,以及提高生物相容性.
MBs提供更安全,非侵入性和局部化药物输送,增加透率和减少全身毒性.
MBs发电机在包括医学,化学和环境科学在内的多个领域中得到了广泛的应用.

研究的目的:

研究微气泡作为内牙科局部药物输送机制的有效性.
为了确定微气泡输液是否增强内牙药物和灌剂的管状透.
评估微气泡对根管消毒中的抗菌活性的影响.

主要方法:

来自单根牙的牙圆柱被Enterococcus faecalis感染.
样品被分为两组:带有和没有MB输液的三重抗生素糊 (TAP).
细菌活力在14天后使用共聚焦激光扫描显微镜进行评估.

主要成果:

与对照组 (单独TAP) 相比,用微泡注入三重抗生素糊的治疗组显示出明显更高的抗菌疗效.
两组之间在细菌减少方面观察到统计学上显著的差异 (P <0.05).
微泡注入导致牙样本的增强消毒.

结论:

微气泡输液显著提高了内牙药物的抗菌疗效.
MB输液是一种可行的新技术,用于增强根管消毒.
这种方法有可能成为内牙治疗中先进的局部药物输送系统.

关键词:

菌 (Enterococcus faecalis) 是一种菌.内通道内药物药物治疗微气泡是一种微气泡.三重抗生素粘贴是一种抗生素粘贴.和抗菌效果的有效性.

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