成人器官移植的生存趋势
Grant Patrick1, Brian Hickner2, Karthik Goli1
1From the Department of Student Affairs, Baylor College of Medicine, Houston, Texas.
概括
肝脏,心脏和肺部移植的治疗意图生存率有所改善,但由于移植率下降,脏移植的生存率下降. 这突出了影响患者结果的器官供应挑战.
科学领域:
- 移植医学 移植医学
- 公共卫生 公共卫生
- 器官捐赠器官捐赠器官捐赠器官捐赠器官捐赠器官捐赠器官捐赠器官捐赠器官捐献器官捐献器官捐献器官捐献器官捐献器官捐献器官捐献器官捐献器官捐献器官捐献器官捐献器官捐献器官捐献器官捐献器官捐献器官捐献器官捐献器官捐献器官捐献器官捐献器官捐献器官捐献器官捐献器官捐献器官捐献器
背景情况:
- 现有研究表明,成年人脏,肝脏,心脏和肺部移植的等待名单和移植后生存率有所进展.
- 对患者和家人来说,需要对移植结果有一个全面的视角.
研究的目的:
- 在成年固体器官移植中分析治疗意图生存率.
- 提供成人固体器官移植进展的整体范围.
主要方法:
- 对813,862名成年人进行治疗意向分析,这些成年人被列为脏,肝脏,心脏和肺部移植.
- 单变量和多变量考克斯回归分析生存因子.
- 卡普兰-梅尔方法用于生存率的变化和移植率的奇平方测试.
主要成果:
- 肝脏,心脏和肺部移植的治疗意图生存率增加.
- 一年内移植率在心脏和肺部显著增加,但在脏方面下降.
- 尽管等待名单和移植后生存率有所改善,但脏治疗意图生存率下降,这与移植率降低有关.
结论:
- 30年来,肝脏,心脏和肺部移植的治疗意图生存率有所改善.
- 分配,免疫抑制和患者护理方面的进步有助于改善结果.
- 移植捐赠者的供需差距越来越大,阻碍了移植存活率的进展.
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