尼日利亚三级医院的HAART治疗HIV阳性患者的功能障碍:一项比较研究
Chukwunonso Gilbert Nwatarali1, Manmak Helen Mamven2, Oluseyi Ademola Adejumo3
1Department of Medicine, University of Abuja Teaching Hospital Gwagwalada, Nigeria.
概括
高活性抗逆转录病毒疗法 (HAART) 改善了艾滋病毒感染者 (PLWHIV) 的治疗结果. 然而,基于丁诺福维尔的HAART与脏功能障碍的风险增加有关,特别是球膜过率下降和近壁管状问题.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學專業.
- 传染性疾病 传染性疾病
- 药理学 药理学是指药理学的学科.
背景情况:
- 高活性抗逆转录病毒疗法 (HAART) 显著改善了人类免疫缺陷病毒 (PLWHIV) 感染者的治疗结果.
- 使用HAART的PLWHIV患者的预期寿命增加与毒性更高的风险有关.
- 这项研究调查了基于tenofovir治疗的PLWHIV患者的功能障碍与非基于tenofovir治疗的HAART.
研究的目的:
- 为了比较基于tenofovir和非基于tenofovir的HAART的PLWHIV之间的球和管状功能障碍.
- 评估含有天诺福维尔的疗法对PLWHIV患者功能的影响.
- 在这个人群中确定与HAART相关的功能障碍的特定标志物.
主要方法:
- 采用了一个比较的横截面研究设计.
- 用脏疾病饮食修改 (MDRD) 公式估计了淋巴细胞过率 (GFR).
- 用尿中的β2-微型血球蛋白,二碳酸盐,尿酸和酸水平的分量分泌来评估近端管状功能.
主要成果:
- 靠近脏管管功能障碍的患病率在基于tenofovir的HAART组 (15.0%) 与非基于tenofovir的组 (3.3%) 相比较高.
- 在接受基于tenofovir的HAART的患者中,尿液中的平均β2-微型血球蛋白水平显著更高.
- 估计的GFR在基于tenofovir的HAART组明显低于非基于tenofovir的组.
结论:
- 基于tenofovir的HAART与GFR显著下降和近端管功能障碍增加有关.
- 定期监测功能,特别是管状功能障碍标志物,建议在基于tenofovir的HAART上对PLWHIV进行监测.
- 这些发现凸显了需要在接受含有天诺福维尔的抗逆转录病毒治疗的艾滋病毒患者中进行仔细的脏监测.
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