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肉瘤的3D模型:为个性化医学提供下一代工具

Ruiling Xu^1,2, Ruiqi Chen^1,2, Chao Tu^1,2

¹Department of Orthopaedics, The Second Xiangya Hospital, Central South University, No. 139 Renmin Road, Changsha, 410011 Hunan China.

Phenomics (Cham, Switzerland)

|June 17, 2024

概括

三维 (3D) 瘤器官提供了一个更具代表性的体外模型来研究这种复杂的癌症. 这些有机体对药物查,生物银行和开发个性化的肉瘤疗法充满希望.

科学领域:

在瘤学瘤学.
生物技术是生物技术.
癌症研究癌症研究

背景情况:

瘤是一种复杂,异质的癌症,使用传统的二维细胞培养和小鼠模型进行研究具有挑战性.
现有的体外模型往往无法完全回顾肉瘤的体内复杂性.

研究的目的:

审查三维 (3D) 肉瘤有机体培养系统的最新进展.
突出瘤有机体作为药物查,生物银行和机制研究工具的潜力.
讨论有机体在理解基因调节,耐药性,转移和肉瘤中的免疫相互作用方面的有用性.

主要方法:

审查关于肉瘤有机体的发展和应用的当前文献.
分析了利用有机体来模拟肉瘤生物学研究的分析.
专注于将有机体发现转化为临床应用.

主要成果:

瘤器官在体外环境中成功地保留了体内瘤生物学中的关键特征.
器官体是研究肉瘤复杂生物机制的有效平台.
器官模型表明,在肉瘤治疗中,个性化医疗方法具有显著的潜力.

结论:

与传统方法相比,瘤器官是一种更准确,更有前途的体外模型.
这些3D系统对于推进肉瘤的翻译研究具有价值.
器官技术可能为为个人肉瘤患者开发量身定制的疗法铺平道路.

关键词:

3D文化是一个3D文化.药物查是指对药物进行查.有机器人机器人机器人机器人个性化医疗是个性化的医疗.肉瘤肉瘤是一种肉瘤.

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